Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children

Mahmood Nejabat; Fatemeh Heidary; Mohammad Reza Talebnejad; Ramin Salouti; Mohammad Hossein Nowroozzadeh; Masoumeh Masoumpour; Hamideh Mahdaviazad; Zahra Tajbakhsh; Maryam Keshtkar; Hossein Jamali; Mohammad Reza Khalili; Hossein Movahedan; Narges Roustaei; Reza Gharebaghi

doi:10.1007/s40123-016-0063-5

Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children

Mahmood Nejabat, Fatemeh Heidary, Mohammad Reza Talebnejad, Ramin Salouti, Mohammad Hossein Nowroozzadeh, Masoumeh Masoumpour, Hamideh Mahdaviazad, Zahra Tajbakhsh, Maryam Keshtkar, Hossein Jamali, Mohammad Reza Khalili, Hossein Movahedan, Narges Roustaei, Reza Gharebaghi

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Introduction: This study aimed to determine intraocular pressure (IOP) and central corneal thickness (CCT) measurements in healthy Persian children to find clinical reference values in this ethnicity. Additionally, we examined the possible relationship between these measurements. Methods: This cross-sectional study included 262 eyes of 131 Persian primary school children between 6 and 13 years of age. All eyes were healthy and had no anterior or posterior segment abnormalities, corneal disease, or evidence of glaucoma. Specular microscopy was used to measure CCT and both noncontact tonometry (NCT) and Goldmann applanation tonometer (GAT) were used to measure IOP. Correlations between IOP measurements were also examined. Results: Mean CCT was 513.47 ± 34.51 μm in the right eye (OD) and 513.93 ± 33.88 μm in the left eye (OS). The CCT was not significantly different between older (10–13 years) and younger (6–9 years) patients. Mean IOP measured with GAT was 13.86 ± 2.13 mmHg OD and 13.72 ± 2.04 mmHg OS and mean IOP measured with NCT was 15.26 ± 2.38 mmHg OD and 15.11 ± 2.18 mmHg OS. The IOP and CCT measured with GAT were weakly correlated (OD: r = 0.141, P = 0.114; OS: r = 0.236, P = 0.007). However, IOP and CCT measured with NCT (OD: r = 0.487, P = 0.000; OS: r = 0.456, P = 0.000) were moderately correlated. Our outcomes demonstrated that for 100 μm increase in CCT, IOP measured with GAT and NCT increased by 0.8 and 3.3 mmHg, respectively, in OD and by 1.4 and 2.9 mmHg in OS. Based on intraclass correlation coefficients, IOP measurements made with GAT and NCT were in fair agreement in OD and in good agreement in OS. Conclusion: The IOP and CCT in healthy Persian school children (6–13 years old) were positively correlated. Our findings revealed that corneal thickness is thinner in Persian children than in most other racial groups. Funding: This study has been funded by deputy dean in research of School of Medicine and deputy vice chancellor of Shiraz University of Medical Sciences, Shiraz, Iran.

Original language	English
Pages (from-to)	235-243
Number of pages	9
Journal	Ophthalmology and Therapy
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/s40123-016-0063-5
Publication status	Published - 1 Dec 2016
Externally published	Yes

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Nejabat, M., Heidary, F., Talebnejad, M. R., Salouti, R., Nowroozzadeh, M. H., Masoumpour, M., Mahdaviazad, H., Tajbakhsh, Z., Keshtkar, M., Jamali, H., Khalili, M. R., Movahedan, H., Roustaei, N., & Gharebaghi, R. (2016). Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children. Ophthalmology and Therapy, 5(2), 235-243. https://doi.org/10.1007/s40123-016-0063-5

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title = "Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children",

abstract = "Introduction: This study aimed to determine intraocular pressure (IOP) and central corneal thickness (CCT) measurements in healthy Persian children to find clinical reference values in this ethnicity. Additionally, we examined the possible relationship between these measurements. Methods: This cross-sectional study included 262 eyes of 131 Persian primary school children between 6 and 13 years of age. All eyes were healthy and had no anterior or posterior segment abnormalities, corneal disease, or evidence of glaucoma. Specular microscopy was used to measure CCT and both noncontact tonometry (NCT) and Goldmann applanation tonometer (GAT) were used to measure IOP. Correlations between IOP measurements were also examined. Results: Mean CCT was 513.47 ± 34.51 μm in the right eye (OD) and 513.93 ± 33.88 μm in the left eye (OS). The CCT was not significantly different between older (10–13 years) and younger (6–9 years) patients. Mean IOP measured with GAT was 13.86 ± 2.13 mmHg OD and 13.72 ± 2.04 mmHg OS and mean IOP measured with NCT was 15.26 ± 2.38 mmHg OD and 15.11 ± 2.18 mmHg OS. The IOP and CCT measured with GAT were weakly correlated (OD: r = 0.141, P = 0.114; OS: r = 0.236, P = 0.007). However, IOP and CCT measured with NCT (OD: r = 0.487, P = 0.000; OS: r = 0.456, P = 0.000) were moderately correlated. Our outcomes demonstrated that for 100 μm increase in CCT, IOP measured with GAT and NCT increased by 0.8 and 3.3 mmHg, respectively, in OD and by 1.4 and 2.9 mmHg in OS. Based on intraclass correlation coefficients, IOP measurements made with GAT and NCT were in fair agreement in OD and in good agreement in OS. Conclusion: The IOP and CCT in healthy Persian school children (6–13 years old) were positively correlated. Our findings revealed that corneal thickness is thinner in Persian children than in most other racial groups. Funding: This study has been funded by deputy dean in research of School of Medicine and deputy vice chancellor of Shiraz University of Medical Sciences, Shiraz, Iran.",

keywords = "Central corneal thickness, Intraocular pressure, Pediatric, Persian race",

author = "Mahmood Nejabat and Fatemeh Heidary and Talebnejad, {Mohammad Reza} and Ramin Salouti and Nowroozzadeh, {Mohammad Hossein} and Masoumeh Masoumpour and Hamideh Mahdaviazad and Zahra Tajbakhsh and Maryam Keshtkar and Hossein Jamali and Khalili, {Mohammad Reza} and Hossein Movahedan and Narges Roustaei and Reza Gharebaghi",

note = "Publisher Copyright: {\textcopyright} 2016, The Author(s).",

year = "2016",

month = dec,

day = "1",

doi = "10.1007/s40123-016-0063-5",

language = "English",

volume = "5",

pages = "235--243",

journal = "Ophthalmology and Therapy",

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Nejabat, M, Heidary, F, Talebnejad, MR, Salouti, R, Nowroozzadeh, MH, Masoumpour, M, Mahdaviazad, H, Tajbakhsh, Z, Keshtkar, M, Jamali, H, Khalili, MR, Movahedan, H, Roustaei, N & Gharebaghi, R 2016, 'Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children', Ophthalmology and Therapy, vol. 5, no. 2, pp. 235-243. https://doi.org/10.1007/s40123-016-0063-5

TY - JOUR

T1 - Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children

AU - Nejabat, Mahmood

AU - Heidary, Fatemeh

AU - Talebnejad, Mohammad Reza

AU - Salouti, Ramin

AU - Nowroozzadeh, Mohammad Hossein

AU - Masoumpour, Masoumeh

AU - Mahdaviazad, Hamideh

AU - Tajbakhsh, Zahra

AU - Keshtkar, Maryam

AU - Jamali, Hossein

AU - Khalili, Mohammad Reza

AU - Movahedan, Hossein

AU - Roustaei, Narges

AU - Gharebaghi, Reza

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Introduction: This study aimed to determine intraocular pressure (IOP) and central corneal thickness (CCT) measurements in healthy Persian children to find clinical reference values in this ethnicity. Additionally, we examined the possible relationship between these measurements. Methods: This cross-sectional study included 262 eyes of 131 Persian primary school children between 6 and 13 years of age. All eyes were healthy and had no anterior or posterior segment abnormalities, corneal disease, or evidence of glaucoma. Specular microscopy was used to measure CCT and both noncontact tonometry (NCT) and Goldmann applanation tonometer (GAT) were used to measure IOP. Correlations between IOP measurements were also examined. Results: Mean CCT was 513.47 ± 34.51 μm in the right eye (OD) and 513.93 ± 33.88 μm in the left eye (OS). The CCT was not significantly different between older (10–13 years) and younger (6–9 years) patients. Mean IOP measured with GAT was 13.86 ± 2.13 mmHg OD and 13.72 ± 2.04 mmHg OS and mean IOP measured with NCT was 15.26 ± 2.38 mmHg OD and 15.11 ± 2.18 mmHg OS. The IOP and CCT measured with GAT were weakly correlated (OD: r = 0.141, P = 0.114; OS: r = 0.236, P = 0.007). However, IOP and CCT measured with NCT (OD: r = 0.487, P = 0.000; OS: r = 0.456, P = 0.000) were moderately correlated. Our outcomes demonstrated that for 100 μm increase in CCT, IOP measured with GAT and NCT increased by 0.8 and 3.3 mmHg, respectively, in OD and by 1.4 and 2.9 mmHg in OS. Based on intraclass correlation coefficients, IOP measurements made with GAT and NCT were in fair agreement in OD and in good agreement in OS. Conclusion: The IOP and CCT in healthy Persian school children (6–13 years old) were positively correlated. Our findings revealed that corneal thickness is thinner in Persian children than in most other racial groups. Funding: This study has been funded by deputy dean in research of School of Medicine and deputy vice chancellor of Shiraz University of Medical Sciences, Shiraz, Iran.

AB - Introduction: This study aimed to determine intraocular pressure (IOP) and central corneal thickness (CCT) measurements in healthy Persian children to find clinical reference values in this ethnicity. Additionally, we examined the possible relationship between these measurements. Methods: This cross-sectional study included 262 eyes of 131 Persian primary school children between 6 and 13 years of age. All eyes were healthy and had no anterior or posterior segment abnormalities, corneal disease, or evidence of glaucoma. Specular microscopy was used to measure CCT and both noncontact tonometry (NCT) and Goldmann applanation tonometer (GAT) were used to measure IOP. Correlations between IOP measurements were also examined. Results: Mean CCT was 513.47 ± 34.51 μm in the right eye (OD) and 513.93 ± 33.88 μm in the left eye (OS). The CCT was not significantly different between older (10–13 years) and younger (6–9 years) patients. Mean IOP measured with GAT was 13.86 ± 2.13 mmHg OD and 13.72 ± 2.04 mmHg OS and mean IOP measured with NCT was 15.26 ± 2.38 mmHg OD and 15.11 ± 2.18 mmHg OS. The IOP and CCT measured with GAT were weakly correlated (OD: r = 0.141, P = 0.114; OS: r = 0.236, P = 0.007). However, IOP and CCT measured with NCT (OD: r = 0.487, P = 0.000; OS: r = 0.456, P = 0.000) were moderately correlated. Our outcomes demonstrated that for 100 μm increase in CCT, IOP measured with GAT and NCT increased by 0.8 and 3.3 mmHg, respectively, in OD and by 1.4 and 2.9 mmHg in OS. Based on intraclass correlation coefficients, IOP measurements made with GAT and NCT were in fair agreement in OD and in good agreement in OS. Conclusion: The IOP and CCT in healthy Persian school children (6–13 years old) were positively correlated. Our findings revealed that corneal thickness is thinner in Persian children than in most other racial groups. Funding: This study has been funded by deputy dean in research of School of Medicine and deputy vice chancellor of Shiraz University of Medical Sciences, Shiraz, Iran.

KW - Central corneal thickness

KW - Intraocular pressure

KW - Pediatric

KW - Persian race

UR - http://www.scopus.com/inward/record.url?scp=85050579019&partnerID=8YFLogxK

U2 - 10.1007/s40123-016-0063-5

DO - 10.1007/s40123-016-0063-5

M3 - Article

AN - SCOPUS:85050579019

SN - 2193-8245

VL - 5

SP - 235

EP - 243

JO - Ophthalmology and Therapy

JF - Ophthalmology and Therapy

IS - 2

ER -

Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children

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