Controlling complexity: the clinical relevance of mouse complex genetics

K. Schughart, C. Libert, M.J. Kas, P. Andreux, A.M. Aransay, J. Auwerx, R. Balling, S. Banerjee, A. Bezerianos, A.D. Bragonzi, G.A. Brockmann, S. Brown, J. Campbell-Tofte, J. Cendelin, A. Chatziioannou, D. Chen, W. Crusio, K. Dimitrakopoulou, J.M. Falcon, J. ForejtP. Franken, L.F. Fröhlich, Y. Herault, I. Hovatta, F.A. Iraqi, R.C. Jansen, L. Kaczmarek, M. Kas, E. Knapska, S. Koks, F. Kolisis, M. Korostynski, F. Lammert, H. Lehrach, A. Lengeling, X. Montagutelli, Grant Morahan, R. Mott, J-J. Panthier, R. Przewlocki, A. Ranki, J. Santos, F. Severcan, L. Schalkwyk, A.B. Smit, A. Terasmaa, E. Vasar, K. Zatloukal

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.
Original languageEnglish
Pages (from-to)1191-1196
Number of pages6
JournalEuropean Journal of Human Genetics
Volume21
Early online date1 May 2013
DOIs
Publication statusPublished - Nov 2013

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