Controlling complexity: the clinical relevance of mouse complex genetics

K. Schughart; C. Libert; M.J. Kas; P. Andreux; A.M. Aransay; J. Auwerx; R. Balling; S. Banerjee; A. Bezerianos; A.D. Bragonzi; G.A. Brockmann; S. Brown; J. Campbell-Tofte; J. Cendelin; A. Chatziioannou; D. Chen; W. Crusio; K. Dimitrakopoulou; J.M. Falcon; J. Forejt; P. Franken; L.F. Fröhlich; Y. Herault; I. Hovatta; F.A. Iraqi; R.C. Jansen; L. Kaczmarek; M. Kas; E. Knapska; S. Koks; F. Kolisis; M. Korostynski; F. Lammert; H. Lehrach; A. Lengeling; X. Montagutelli; Grant Morahan; R. Mott; J-J. Panthier; R. Przewlocki; A. Ranki; J. Santos; F. Severcan; L. Schalkwyk; A.B. Smit; A. Terasmaa; E. Vasar; K. Zatloukal

doi:10.1038/ejhg.2013.79

Controlling complexity: the clinical relevance of mouse complex genetics

K. Schughart, C. Libert, M.J. Kas, P. Andreux, A.M. Aransay, J. Auwerx, R. Balling, S. Banerjee, A. Bezerianos, A.D. Bragonzi, G.A. Brockmann, S. Brown, J. Campbell-Tofte, J. Cendelin, A. Chatziioannou, D. Chen, W. Crusio, K. Dimitrakopoulou, J.M. Falcon, J. ForejtP. Franken, L.F. Fröhlich, Y. Herault, I. Hovatta, F.A. Iraqi, R.C. Jansen, L. Kaczmarek, M. Kas, E. Knapska, S. Koks, F. Kolisis, M. Korostynski, F. Lammert, H. Lehrach, A. Lengeling, X. Montagutelli, Grant Morahan, R. Mott, J-J. Panthier, R. Przewlocki, A. Ranki, J. Santos, F. Severcan, L. Schalkwyk, A.B. Smit, A. Terasmaa, E. Vasar, K. Zatloukal

UWA Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research)

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.

Original language	English
Pages (from-to)	1191-1196
Number of pages	6
Journal	European Journal of Human Genetics
Volume	21
Early online date	1 May 2013
DOIs	https://doi.org/10.1038/ejhg.2013.79
Publication status	Published - Nov 2013

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Schughart, K., Libert, C., Kas, M. J., Andreux, P., Aransay, A. M., Auwerx, J., Balling, R., Banerjee, S., Bezerianos, A., Bragonzi, A. D., Brockmann, G. A., Brown, S., Campbell-Tofte, J., Cendelin, J., Chatziioannou, A., Chen, D., Crusio, W., Dimitrakopoulou, K., Falcon, J. M., ... Zatloukal, K. (2013). Controlling complexity: the clinical relevance of mouse complex genetics. European Journal of Human Genetics, 21, 1191-1196. https://doi.org/10.1038/ejhg.2013.79

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title = "Controlling complexity: the clinical relevance of mouse complex genetics",

abstract = "Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.",

author = "K. Schughart and C. Libert and M.J. Kas and P. Andreux and A.M. Aransay and J. Auwerx and R. Balling and S. Banerjee and A. Bezerianos and A.D. Bragonzi and G.A. Brockmann and S. Brown and J. Campbell-Tofte and J. Cendelin and A. Chatziioannou and D. Chen and W. Crusio and K. Dimitrakopoulou and J.M. Falcon and J. Forejt and P. Franken and L.F. Fr{\"o}hlich and Y. Herault and I. Hovatta and F.A. Iraqi and R.C. Jansen and L. Kaczmarek and M. Kas and E. Knapska and S. Koks and F. Kolisis and M. Korostynski and F. Lammert and H. Lehrach and A. Lengeling and X. Montagutelli and Grant Morahan and R. Mott and J-J. Panthier and R. Przewlocki and A. Ranki and J. Santos and F. Severcan and L. Schalkwyk and A.B. Smit and A. Terasmaa and E. Vasar and K. Zatloukal",

year = "2013",

month = nov,

doi = "10.1038/ejhg.2013.79",

language = "English",

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pages = "1191--1196",

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Schughart, K, Libert, C, Kas, MJ, Andreux, P, Aransay, AM, Auwerx, J, Balling, R, Banerjee, S, Bezerianos, A, Bragonzi, AD, Brockmann, GA, Brown, S, Campbell-Tofte, J, Cendelin, J, Chatziioannou, A, Chen, D, Crusio, W, Dimitrakopoulou, K, Falcon, JM, Forejt, J, Franken, P, Fröhlich, LF, Herault, Y, Hovatta, I, Iraqi, FA, Jansen, RC, Kaczmarek, L, Kas, M, Knapska, E, Koks, S, Kolisis, F, Korostynski, M, Lammert, F, Lehrach, H, Lengeling, A, Montagutelli, X, Morahan, G, Mott, R, Panthier, J-J, Przewlocki, R, Ranki, A, Santos, J, Severcan, F, Schalkwyk, L, Smit, AB, Terasmaa, A, Vasar, E & Zatloukal, K 2013, 'Controlling complexity: the clinical relevance of mouse complex genetics', European Journal of Human Genetics, vol. 21, pp. 1191-1196. https://doi.org/10.1038/ejhg.2013.79

TY - JOUR

T1 - Controlling complexity: the clinical relevance of mouse complex genetics

AU - Schughart, K.

AU - Libert, C.

AU - Kas, M.J.

AU - Andreux, P.

AU - Aransay, A.M.

AU - Auwerx, J.

AU - Balling, R.

AU - Banerjee, S.

AU - Bezerianos, A.

AU - Bragonzi, A.D.

AU - Brockmann, G.A.

AU - Brown, S.

AU - Campbell-Tofte, J.

AU - Cendelin, J.

AU - Chatziioannou, A.

AU - Chen, D.

AU - Crusio, W.

AU - Dimitrakopoulou, K.

AU - Falcon, J.M.

AU - Forejt, J.

AU - Franken, P.

AU - Fröhlich, L.F.

AU - Herault, Y.

AU - Hovatta, I.

AU - Iraqi, F.A.

AU - Jansen, R.C.

AU - Kaczmarek, L.

AU - Kas, M.

AU - Knapska, E.

AU - Koks, S.

AU - Kolisis, F.

AU - Korostynski, M.

AU - Lammert, F.

AU - Lehrach, H.

AU - Lengeling, A.

AU - Montagutelli, X.

AU - Morahan, Grant

AU - Mott, R.

AU - Panthier, J-J.

AU - Przewlocki, R.

AU - Ranki, A.

AU - Santos, J.

AU - Severcan, F.

AU - Schalkwyk, L.

AU - Smit, A.B.

AU - Terasmaa, A.

AU - Vasar, E.

AU - Zatloukal, K.

PY - 2013/11

Y1 - 2013/11

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AB - Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.

U2 - 10.1038/ejhg.2013.79

DO - 10.1038/ejhg.2013.79

M3 - Article

C2 - 23632795

SN - 1018-4813

VL - 21

SP - 1191

EP - 1196

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

ER -

Controlling complexity: the clinical relevance of mouse complex genetics

Abstract

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