Controlled release of Berberine Chloride by electrospun core/shell PVP/PLCL fibrous membranes

Bin Sun; Shuo Li; Hong Zhang; Hua Li; Chenguang Zhao; Xiaoyan Yuan; Yuanlu Cui

doi:10.1504/IJMPT.2010.031433

Controlled release of Berberine Chloride by electrospun core/shell PVP/PLCL fibrous membranes

Bin Sun, Shuo Li, Hong Zhang, Hua Li, Chenguang Zhao, Xiaoyan Yuan, Yuanlu Cui

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Berberine chloride (BC) was loaded in the core/shell structured poly(vinyl pyrrolidone)/poly(L-lactide-co-ε-caprolactone) (PVP/PLCL) by coaxial electrospinning. After hot-press at 60°C, the mechanical properties of the electrospun PVP/PLCL membrane increased significantly. A burst release of BC from the electrospun PVP/PLCL fibres incubated in PBS at 37°C was found in 1 h and the cumulative released percentage of BC could exceed 90% at 72 h, significantly higher than that of BC encapsulated in PLCL. The drug-loaded electrospun PVP/PLCL membranes could potentially enhance wound healing in skin repair.

Original language	English
Pages (from-to)	338-349
Number of pages	12
Journal	International Journal of Materials and Product Technology
Volume	37
Issue number	3-4
DOIs	https://doi.org/10.1504/IJMPT.2010.031433
Publication status	Published - Feb 2010
Externally published	Yes

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10.1504/IJMPT.2010.031433

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title = "Controlled release of Berberine Chloride by electrospun core/shell PVP/PLCL fibrous membranes",

abstract = "Berberine chloride (BC) was loaded in the core/shell structured poly(vinyl pyrrolidone)/poly(L-lactide-co-ε-caprolactone) (PVP/PLCL) by coaxial electrospinning. After hot-press at 60°C, the mechanical properties of the electrospun PVP/PLCL membrane increased significantly. A burst release of BC from the electrospun PVP/PLCL fibres incubated in PBS at 37°C was found in 1 h and the cumulative released percentage of BC could exceed 90\% at 72 h, significantly higher than that of BC encapsulated in PLCL. The drug-loaded electrospun PVP/PLCL membranes could potentially enhance wound healing in skin repair.",

keywords = "BC, Berberine chloride, Coaxial electrospinning, Controlled release, Hot-press, Wound dressing",

author = "Bin Sun and Shuo Li and Hong Zhang and Hua Li and Chenguang Zhao and Xiaoyan Yuan and Yuanlu Cui",

year = "2010",

month = feb,

doi = "10.1504/IJMPT.2010.031433",

language = "English",

volume = "37",

pages = "338--349",

journal = "International Journal of Materials and Product Technology",

issn = "0268-1900",

publisher = "Inderscience Enterprises",

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TY - JOUR

T1 - Controlled release of Berberine Chloride by electrospun core/shell PVP/PLCL fibrous membranes

AU - Sun, Bin

AU - Li, Shuo

AU - Zhang, Hong

AU - Li, Hua

AU - Zhao, Chenguang

AU - Yuan, Xiaoyan

AU - Cui, Yuanlu

PY - 2010/2

Y1 - 2010/2

N2 - Berberine chloride (BC) was loaded in the core/shell structured poly(vinyl pyrrolidone)/poly(L-lactide-co-ε-caprolactone) (PVP/PLCL) by coaxial electrospinning. After hot-press at 60°C, the mechanical properties of the electrospun PVP/PLCL membrane increased significantly. A burst release of BC from the electrospun PVP/PLCL fibres incubated in PBS at 37°C was found in 1 h and the cumulative released percentage of BC could exceed 90% at 72 h, significantly higher than that of BC encapsulated in PLCL. The drug-loaded electrospun PVP/PLCL membranes could potentially enhance wound healing in skin repair.

AB - Berberine chloride (BC) was loaded in the core/shell structured poly(vinyl pyrrolidone)/poly(L-lactide-co-ε-caprolactone) (PVP/PLCL) by coaxial electrospinning. After hot-press at 60°C, the mechanical properties of the electrospun PVP/PLCL membrane increased significantly. A burst release of BC from the electrospun PVP/PLCL fibres incubated in PBS at 37°C was found in 1 h and the cumulative released percentage of BC could exceed 90% at 72 h, significantly higher than that of BC encapsulated in PLCL. The drug-loaded electrospun PVP/PLCL membranes could potentially enhance wound healing in skin repair.

KW - BC

KW - Berberine chloride

KW - Coaxial electrospinning

KW - Controlled release

KW - Hot-press

KW - Wound dressing

UR - https://www.scopus.com/pages/publications/76449097523

U2 - 10.1504/IJMPT.2010.031433

DO - 10.1504/IJMPT.2010.031433

M3 - Article

AN - SCOPUS:76449097523

SN - 0268-1900

VL - 37

SP - 338

EP - 349

JO - International Journal of Materials and Product Technology

JF - International Journal of Materials and Product Technology

IS - 3-4

ER -

Controlled release of Berberine Chloride by electrospun core/shell PVP/PLCL fibrous membranes

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