Control of early HIV-1 infection associates with plasmacytoid dendritic cell-reactive opsonophagocytic IgG antibodies to HIV-1 p24

M. Christian Tjiam, Lucy Sariputra, Jesse D. Armitage, James P. A. Taylor, A.D. Kelleher, Dino B. A. Tan, Silvia Lee, Sonia Fernandez, Martyn A. French

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    Abstract

    © 2016 Wolters Kluwer Health, Inc. All rights reserved.
    Objectives: We have previously demonstrated that HIV-1 p24-specific plasmacytoid dendritic cell-reactive opsonophagocytic antibody (PROAb) responses associate with control of chronic HIV infection. Here, we examined whether HIV-1 p24-specific PROAbs associate with control of early HIV infection and their relationship with HIV-1 p24-specific IgG subclasses. Methods: Plasma collected at 8 and 52 weeks following primary HIV-1 infection was obtained from antiretroviral therapy-naïve patients who were classified as 'good' (plasma HIV-1 RNA50 000 copies/ml; n=15) controllers at week 52. HIV-1 p24-specific PROAb responses were assayed using a plasmacytoid dendritic cell line (Gen2.2), and HIV-1 p24-specific IgG3, IgG1 and IgG2 levels were assayed by ELISA. Results: HIV-1 p24-specific PROAb responses increased in 'good controllers' (P=0.01) but remained unchanged in 'poor controllers' between weeks 8 and 52. Of the HIV-1 p24-specific IgG subclasses measured, only IgG1 increased over this time period in 'good controllers' alone (P=0.003), which correlated with the increase in HIV-1 p24-specific PROAb responses (r=0.83, P
    Original languageEnglish
    Pages (from-to)2757-2765
    JournalAIDS
    Volume30
    Issue number18
    DOIs
    Publication statusPublished - 28 Nov 2016

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