Contribution of renal biopsy data in predicting outcome in lupus nephritis: analysis of 116 patients

Hans C. Nossent, Sonja C. Henzen‐Logmans, Thea M. Vroom, Jo H M Berden, Tom J G Swaak

    Research output: Contribution to journalArticle

    132 Citations (Scopus)

    Abstract

    We reassessed renal biopsy specimens from 116 patients with systemic lupus erythematosus and clinical manifestations of lupus nephritis to determine the contributions of the World Health Organization classification system, the activity and chronicity indexes of the National Institutes of Health scoring system, and various clinical parameters at the time of biopsy to predicting disease outcome. Multivariate analysis showed that only a chronicity index >3 was predictive for decreased renal survival, while age >31 years at biopsy and a chronicity index >3 were associated with decreased patient survival. Clinical tests of renal function were not reliable in discriminating between active lesions and chronic renal damage.

    Original languageEnglish
    Pages (from-to)970-977
    Number of pages8
    JournalArthritis & Rheumatism
    Volume33
    Issue number7
    DOIs
    Publication statusPublished - 1990

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