Contribution of nasal pathways to low frequency respiratory impedance in infants

Zoltan Hantos, J.H. Wildhaber, Z. Hantos, Graham Hall, Peter Sly

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Background: In infants the impedance of the nasal pathways (Zn) is a significant proportion of the total respiratory impedance (Zrs).Methods: In 11 infants Zrs was partitioned into Zn and lower respiratory system impedance (Zlrs) using a nasal catheter. A low frequency oscillatory signal (0.5-20 Hz) was applied during a pause in breathing to obtain the impedance spectra. A model of the respiratory system containing an airway and tissue compartment was then fitted to Zrs and Zlrs. The airway compartment consisted of a frequency independent resistance (R) and inertance (I), while the tissue compartment was described by coefficients of tissue damping (G) and elastance (H).Results: Zrs could be reliably partitioned into Zn and Zlrs. The nasal pathway acted as a purely resistive-inertive impedance and contributed approximately half of the airway resistance (mean (SE) 44.6 (4.9)%) and most of the respiratory system inertance (71.7 (3.5)%).Conclusion: In studies investigating changes in airway resistance in nasally breathing infants, the separation of nasal and lower respiratory system mechanics will increase the sensitivity of the tests.
Original languageEnglish
Pages (from-to)396-399
JournalThorax
Volume57
DOIs
Publication statusPublished - 2002

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