Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes

D. L. Cheung, P. H. Hart, G. F. Vitti, G. A. Whitty, J. A. Hamilton

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Stimulated human monocytes/macrophages are a source of interleukin-6 (IL-6), which is a likely mediator involved in immune and inflammatory reactions. The means to control production of IL-6 by these cells could therefore have therapeutic applications. We report here, for lipopolysaccharide (LPS)-stimulated human monocytes in vitro, that the lymphokine, interferon-gamma (IFN-γ) (100 U/ml), enhanced the level of IL-6 activity, whereas another lymphokine, interleukin-4 (IL-4) (≥0.1 U/ml; ≥1.2 x 10-11M), suppressed it. The effect of the two lymphokines were manifested at the level of mRNA. The action of the IL-4 was similar to that of the glucocorticoid, dexamethasone, but observed at a lower molar concentration. Such regulation of monocyte IL-6 activity is similar to that found previously for interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF-α) synthesis.

Original languageEnglish
Pages (from-to)70-75
Number of pages6
JournalImmunology
Volume71
Issue number1
Publication statusPublished - 1 Jan 1990
Externally publishedYes

Fingerprint Dive into the research topics of 'Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes'. Together they form a unique fingerprint.

Cite this