Contractile effects and receptor distributions for endothelin-1 (ET-1) in human and animal airways.

R. G. Goldie, P. J. Henry, J. W. Paterson, J. M. Preuss, P. J. Rigby

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

ET-1 caused concentration-dependent, sustained contraction of all airway preparations tested and was most potent in mouse trachea, with rat trachea, human bronchus and guinea-pig trachea approximately 5, 10 and 70 fold less sensitive respectively. Human non-asthmatic and asthmatic bronchi were approximately equi-sensitive to ET-1. Quantitative light microscopic autoradiography demonstrated high levels of specific [125I]-ET-1 binding sites in airway smooth muscle of rat trachea greater than human asthmatic bronchus = human non-asthmatic bronchus greater than mouse trachea much greater than guinea-pig trachea. High levels of specific ET-1 binding were also revealed in peripheral airways and in alveolar wall tissue in human, rat and mouse lung. In a limited sample of asthmatic airway smooth muscle ET-1 receptor function and density was not elevated.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalAgents and Actions Supplements
Volume31
Publication statusPublished - 1 Dec 1990

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