Contemporary and Novel Therapeutic Options for Hypertriglyceridemia

    Research output: Contribution to journalLiterature reviewpeer-review

    7 Citations (Scopus)


    PURPOSE: The purpose of this review was to outline the current and emerging therapeutic options for the treatment of hypertriglyceridemia, with an emphasis on emerging therapies.

    METHODS: A systematic literature search was conducted with the use of PubMed and Embase for articles on hypertriglyceridemia, with a focus on therapeutics, pharmacology, and management. Abstracts from recent international meetings were also reviewed for presentations of Phase I and II data on agents with triglyceride-lowering effects. A further review of the references identified from these articles was also performed.

    FINDINGS: Consistent with the multifactorial cause of hypertriglyceridemia, the therapeutic options are broad and numerous. This review explores the current and potential therapeutic options for treating hypertriglyceridemia and outlines the potential mechanisms of action. However, the mechanism of triglyceride reduction is complex, multifactorial, or not fully elucidated for some of these agents. The magnitude of triglyceride reduction and findings of outcome studies are described.

    IMPLICATIONS: Management of hypertriglyceridemia is about to enter an exciting phase, with multiple emerging therapies in the final stages of development. However, caution is warranted, because studies of therapeutic agents over the previous decade have often not found cardiovascular outcome benefits despite encouraging effects on triglyceride concentrations.

    Original languageEnglish
    Pages (from-to)2732-2750
    Number of pages19
    JournalClinical Therapeutics
    Issue number12
    Publication statusPublished - 1 Dec 2015


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