Consumption of a whey protein-enriched diet may prevent hepatic steatosis associated with weight gain in elderly women

Esther Ooi, Leon Adams, Kun Zhu, Joshua Lewis, D.A. Kerr, X. Meng, V. Solah, A. Devine, C.W. Binns, Richard Prince

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    3 Citations (Scopus)

    Abstract

    Background and aims: Protein consumption has been associated with cardio-metabolic benefits, including weight loss and improved insulin sensitivity, and may have potential benefits for individuals with fatty liver disease (FLD). We investigated the effect of increasing dietary protein intake from whey relative to carbohydrate on hepatic steatosis. Methods and results A two-year randomized, double-blind, placebo-controlled trial of 30 g/day whey protein-supplemented beverage (protein) or an energy-matched low-protein high-carbohydrate beverage (control) for cardio-metabolic and bone health in 219 healthy elderly women, recruited from the Western Australian general population. Hepatic steatosis was quantified using computed tomographic liver-to-spleen (L/S) ratio. FLD was defined as liver-to-spleen difference <10 Hounsfield units. At baseline, FLD prevalence was 11.4%. Control and protein groups were similar in body mass index (BMI), insulin resistance, L/S ratio and FLD prevalence at baseline. At two-years, dietary protein increased by 20 g in the protein, but not the control, group. Total energy intake and physical activity remained similar between groups. At two-years, BMI and FLD prevalence increased in both groups, with no between group differences. L/S ratio increased in control, but not protein, group at two-years, with no between group differences. In a within group comparison, change in BMI correlated with changes in L/S ratio in control (r = 0.37, P = 0.0007), but not with protein group (r = 0.04, P = 0.73). Conclusion Increasing dietary protein intake from whey relative to carbohydrate does not reduce weight, hepatic steatosis or the prevalence of FLD in elderly women. However, it may prevent worsening of hepatic steatosis associated with weight gain.
    Original languageEnglish
    Pages (from-to)388-395
    JournalNutrition, Metabolism and Cardiovascular Diseases
    Volume25
    Issue number4
    DOIs
    Publication statusPublished - Apr 2015

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    Weight Gain
    Fatty Liver
    Diet
    Liver Diseases
    Liver
    Spleen
    Dietary Proteins
    Proteins
    Body Mass Index
    Beverages
    Carbohydrates
    Insulin Resistance
    Whey Proteins
    Control Groups
    Energy Intake
    Weight Loss
    Placebos
    Exercise
    Weights and Measures
    Bone and Bones

    Cite this

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    title = "Consumption of a whey protein-enriched diet may prevent hepatic steatosis associated with weight gain in elderly women",
    abstract = "Background and aims: Protein consumption has been associated with cardio-metabolic benefits, including weight loss and improved insulin sensitivity, and may have potential benefits for individuals with fatty liver disease (FLD). We investigated the effect of increasing dietary protein intake from whey relative to carbohydrate on hepatic steatosis. Methods and results A two-year randomized, double-blind, placebo-controlled trial of 30 g/day whey protein-supplemented beverage (protein) or an energy-matched low-protein high-carbohydrate beverage (control) for cardio-metabolic and bone health in 219 healthy elderly women, recruited from the Western Australian general population. Hepatic steatosis was quantified using computed tomographic liver-to-spleen (L/S) ratio. FLD was defined as liver-to-spleen difference <10 Hounsfield units. At baseline, FLD prevalence was 11.4{\%}. Control and protein groups were similar in body mass index (BMI), insulin resistance, L/S ratio and FLD prevalence at baseline. At two-years, dietary protein increased by 20 g in the protein, but not the control, group. Total energy intake and physical activity remained similar between groups. At two-years, BMI and FLD prevalence increased in both groups, with no between group differences. L/S ratio increased in control, but not protein, group at two-years, with no between group differences. In a within group comparison, change in BMI correlated with changes in L/S ratio in control (r = 0.37, P = 0.0007), but not with protein group (r = 0.04, P = 0.73). Conclusion Increasing dietary protein intake from whey relative to carbohydrate does not reduce weight, hepatic steatosis or the prevalence of FLD in elderly women. However, it may prevent worsening of hepatic steatosis associated with weight gain.",
    author = "Esther Ooi and Leon Adams and Kun Zhu and Joshua Lewis and D.A. Kerr and X. Meng and V. Solah and A. Devine and C.W. Binns and Richard Prince",
    year = "2015",
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    language = "English",
    volume = "25",
    pages = "388--395",
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    Consumption of a whey protein-enriched diet may prevent hepatic steatosis associated with weight gain in elderly women. / Ooi, Esther; Adams, Leon; Zhu, Kun; Lewis, Joshua; Kerr, D.A.; Meng, X.; Solah, V.; Devine, A.; Binns, C.W.; Prince, Richard.

    In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 25, No. 4, 04.2015, p. 388-395.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Consumption of a whey protein-enriched diet may prevent hepatic steatosis associated with weight gain in elderly women

    AU - Ooi, Esther

    AU - Adams, Leon

    AU - Zhu, Kun

    AU - Lewis, Joshua

    AU - Kerr, D.A.

    AU - Meng, X.

    AU - Solah, V.

    AU - Devine, A.

    AU - Binns, C.W.

    AU - Prince, Richard

    PY - 2015/4

    Y1 - 2015/4

    N2 - Background and aims: Protein consumption has been associated with cardio-metabolic benefits, including weight loss and improved insulin sensitivity, and may have potential benefits for individuals with fatty liver disease (FLD). We investigated the effect of increasing dietary protein intake from whey relative to carbohydrate on hepatic steatosis. Methods and results A two-year randomized, double-blind, placebo-controlled trial of 30 g/day whey protein-supplemented beverage (protein) or an energy-matched low-protein high-carbohydrate beverage (control) for cardio-metabolic and bone health in 219 healthy elderly women, recruited from the Western Australian general population. Hepatic steatosis was quantified using computed tomographic liver-to-spleen (L/S) ratio. FLD was defined as liver-to-spleen difference <10 Hounsfield units. At baseline, FLD prevalence was 11.4%. Control and protein groups were similar in body mass index (BMI), insulin resistance, L/S ratio and FLD prevalence at baseline. At two-years, dietary protein increased by 20 g in the protein, but not the control, group. Total energy intake and physical activity remained similar between groups. At two-years, BMI and FLD prevalence increased in both groups, with no between group differences. L/S ratio increased in control, but not protein, group at two-years, with no between group differences. In a within group comparison, change in BMI correlated with changes in L/S ratio in control (r = 0.37, P = 0.0007), but not with protein group (r = 0.04, P = 0.73). Conclusion Increasing dietary protein intake from whey relative to carbohydrate does not reduce weight, hepatic steatosis or the prevalence of FLD in elderly women. However, it may prevent worsening of hepatic steatosis associated with weight gain.

    AB - Background and aims: Protein consumption has been associated with cardio-metabolic benefits, including weight loss and improved insulin sensitivity, and may have potential benefits for individuals with fatty liver disease (FLD). We investigated the effect of increasing dietary protein intake from whey relative to carbohydrate on hepatic steatosis. Methods and results A two-year randomized, double-blind, placebo-controlled trial of 30 g/day whey protein-supplemented beverage (protein) or an energy-matched low-protein high-carbohydrate beverage (control) for cardio-metabolic and bone health in 219 healthy elderly women, recruited from the Western Australian general population. Hepatic steatosis was quantified using computed tomographic liver-to-spleen (L/S) ratio. FLD was defined as liver-to-spleen difference <10 Hounsfield units. At baseline, FLD prevalence was 11.4%. Control and protein groups were similar in body mass index (BMI), insulin resistance, L/S ratio and FLD prevalence at baseline. At two-years, dietary protein increased by 20 g in the protein, but not the control, group. Total energy intake and physical activity remained similar between groups. At two-years, BMI and FLD prevalence increased in both groups, with no between group differences. L/S ratio increased in control, but not protein, group at two-years, with no between group differences. In a within group comparison, change in BMI correlated with changes in L/S ratio in control (r = 0.37, P = 0.0007), but not with protein group (r = 0.04, P = 0.73). Conclusion Increasing dietary protein intake from whey relative to carbohydrate does not reduce weight, hepatic steatosis or the prevalence of FLD in elderly women. However, it may prevent worsening of hepatic steatosis associated with weight gain.

    U2 - 10.1016/j.numecd.2014.11.005

    DO - 10.1016/j.numecd.2014.11.005

    M3 - Article

    VL - 25

    SP - 388

    EP - 395

    JO - Nutrition, Metabolism and Cardiovascular Diseases

    JF - Nutrition, Metabolism and Cardiovascular Diseases

    SN - 0939-4753

    IS - 4

    ER -