Construction and evaluation of rodent-specific rTMS coils

Alex Tang, A.S. Lowe, Andrew Garrett, Rob Woodward, W. Bennett, A.J. Canty, M.I. Garry, M.R. Hinder, J.J. Summers, R. Gersner, A. Rotenberg, G. Thickbroom, J. Walton, Jennifer Rodger

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    © 2016 Tang, Lowe, Garrett, Woodward, Bennett, Canty, Garry, Hinder, Summers, Gersner, Rotenberg, Thickbroom, Walton and Rodger.Rodent models of transcranial magnetic stimulation (TMS) play a crucial role in aiding the understanding of the cellular and molecular mechanisms underlying TMS induced plasticity. Rodent-specific TMS have previously been used to deliver focal stimulation at the cost of stimulus intensity (12 mT). Here we describe two novel TMS coils designed to deliver repetitive TMS (rTMS) at greater stimulation intensities whilst maintaining spatial resolution. Two circular coils (8 mm outer diameter) were constructed with either an air or pure iron-core. Peak magnetic field strength for the air and iron-cores were 90 and 120 mT, respectively, with the iron-core coil exhibiting less focality. Coil temperature and magnetic field stability for the two coils undergoing rTMS, were similar at 1 Hz but varied at 10 Hz. Finite element modeling of 10 Hz rTMS with the iron-core in a simplified rat brain model suggests a peak electric field of 85 and 12.7 V/m, within the skull and the brain, respectively. Delivering 10 Hz rTMS to the motor cortex of anaesthetized rats with the iron-core coil significantly increased motor evoked potential amplitudes immediately after stimulation (n = 4). Our results suggest these novel coils generate modest magnetic and electric fields, capable of altering cortical excitability and provide an alternative method to investigate the mechanisms underlying rTMS-induced plasticity in an experimental setting.
    Original languageEnglish
    JournalFrontiers in Neural Circuits
    Volume10
    DOIs
    Publication statusPublished - 30 Jun 2016

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    Transcranial Magnetic Stimulation
    Rodentia
    Iron
    Magnetic Fields
    Air
    Motor Evoked Potentials
    Motor Cortex
    Brain
    Skull
    Temperature

    Cite this

    Tang, Alex ; Lowe, A.S. ; Garrett, Andrew ; Woodward, Rob ; Bennett, W. ; Canty, A.J. ; Garry, M.I. ; Hinder, M.R. ; Summers, J.J. ; Gersner, R. ; Rotenberg, A. ; Thickbroom, G. ; Walton, J. ; Rodger, Jennifer. / Construction and evaluation of rodent-specific rTMS coils. In: Frontiers in Neural Circuits. 2016 ; Vol. 10.
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    author = "Alex Tang and A.S. Lowe and Andrew Garrett and Rob Woodward and W. Bennett and A.J. Canty and M.I. Garry and M.R. Hinder and J.J. Summers and R. Gersner and A. Rotenberg and G. Thickbroom and J. Walton and Jennifer Rodger",
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    Tang, A, Lowe, AS, Garrett, A, Woodward, R, Bennett, W, Canty, AJ, Garry, MI, Hinder, MR, Summers, JJ, Gersner, R, Rotenberg, A, Thickbroom, G, Walton, J & Rodger, J 2016, 'Construction and evaluation of rodent-specific rTMS coils' Frontiers in Neural Circuits, vol. 10. https://doi.org/10.3389/fncir.2016.00047

    Construction and evaluation of rodent-specific rTMS coils. / Tang, Alex; Lowe, A.S.; Garrett, Andrew; Woodward, Rob; Bennett, W.; Canty, A.J.; Garry, M.I.; Hinder, M.R.; Summers, J.J.; Gersner, R.; Rotenberg, A.; Thickbroom, G.; Walton, J.; Rodger, Jennifer.

    In: Frontiers in Neural Circuits, Vol. 10, 30.06.2016.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Construction and evaluation of rodent-specific rTMS coils

    AU - Tang, Alex

    AU - Lowe, A.S.

    AU - Garrett, Andrew

    AU - Woodward, Rob

    AU - Bennett, W.

    AU - Canty, A.J.

    AU - Garry, M.I.

    AU - Hinder, M.R.

    AU - Summers, J.J.

    AU - Gersner, R.

    AU - Rotenberg, A.

    AU - Thickbroom, G.

    AU - Walton, J.

    AU - Rodger, Jennifer

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    N2 - © 2016 Tang, Lowe, Garrett, Woodward, Bennett, Canty, Garry, Hinder, Summers, Gersner, Rotenberg, Thickbroom, Walton and Rodger.Rodent models of transcranial magnetic stimulation (TMS) play a crucial role in aiding the understanding of the cellular and molecular mechanisms underlying TMS induced plasticity. Rodent-specific TMS have previously been used to deliver focal stimulation at the cost of stimulus intensity (12 mT). Here we describe two novel TMS coils designed to deliver repetitive TMS (rTMS) at greater stimulation intensities whilst maintaining spatial resolution. Two circular coils (8 mm outer diameter) were constructed with either an air or pure iron-core. Peak magnetic field strength for the air and iron-cores were 90 and 120 mT, respectively, with the iron-core coil exhibiting less focality. Coil temperature and magnetic field stability for the two coils undergoing rTMS, were similar at 1 Hz but varied at 10 Hz. Finite element modeling of 10 Hz rTMS with the iron-core in a simplified rat brain model suggests a peak electric field of 85 and 12.7 V/m, within the skull and the brain, respectively. Delivering 10 Hz rTMS to the motor cortex of anaesthetized rats with the iron-core coil significantly increased motor evoked potential amplitudes immediately after stimulation (n = 4). Our results suggest these novel coils generate modest magnetic and electric fields, capable of altering cortical excitability and provide an alternative method to investigate the mechanisms underlying rTMS-induced plasticity in an experimental setting.

    AB - © 2016 Tang, Lowe, Garrett, Woodward, Bennett, Canty, Garry, Hinder, Summers, Gersner, Rotenberg, Thickbroom, Walton and Rodger.Rodent models of transcranial magnetic stimulation (TMS) play a crucial role in aiding the understanding of the cellular and molecular mechanisms underlying TMS induced plasticity. Rodent-specific TMS have previously been used to deliver focal stimulation at the cost of stimulus intensity (12 mT). Here we describe two novel TMS coils designed to deliver repetitive TMS (rTMS) at greater stimulation intensities whilst maintaining spatial resolution. Two circular coils (8 mm outer diameter) were constructed with either an air or pure iron-core. Peak magnetic field strength for the air and iron-cores were 90 and 120 mT, respectively, with the iron-core coil exhibiting less focality. Coil temperature and magnetic field stability for the two coils undergoing rTMS, were similar at 1 Hz but varied at 10 Hz. Finite element modeling of 10 Hz rTMS with the iron-core in a simplified rat brain model suggests a peak electric field of 85 and 12.7 V/m, within the skull and the brain, respectively. Delivering 10 Hz rTMS to the motor cortex of anaesthetized rats with the iron-core coil significantly increased motor evoked potential amplitudes immediately after stimulation (n = 4). Our results suggest these novel coils generate modest magnetic and electric fields, capable of altering cortical excitability and provide an alternative method to investigate the mechanisms underlying rTMS-induced plasticity in an experimental setting.

    U2 - 10.3389/fncir.2016.00047

    DO - 10.3389/fncir.2016.00047

    M3 - Article

    VL - 10

    JO - Frontiers in Neural Circuits

    JF - Frontiers in Neural Circuits

    SN - 1662-5110

    ER -