Constitutive modelling of lamb aorta

Research output: Chapter in Book/Conference paperChapter

Abstract

Vascular inflammation is an established marker of cardiovascular pathogenesis, particularly atherosclerosis, but its role on arterial tissue biomechanics is not well understood. Its impact on the biomechanics of the aorta can yield valuable data for elucidating its role in disease formation, as well as leading to the development of valuable predictive models for surgery and new treatments. Changes in arterial biomechanics can lead to arterial remodelling and dysfunction, and so its quantification can provide insight into the nature of inflammatory processes. To gain further insight into these processes we investigated the biomechanical behaviour of lamb aortas from inflamed and control groups through the development of a constitutive model. The development of reliable constitutive models of the artery is necessary in order to fully understand the mechanical component of cardiovascular disease pathogenesis and vascular remodelling. We used a foetal sheep model of systemic inflammation induced by prenatal lipopolysaccharide (LPS) treatment (n = 6) to investigate the effects of short-term inflammation on the passive biomechanical response of the aorta. We subjected samples cut from aortas (LPS, n = 6; control, n = 4) to uniaxial tension testing until failure, measuring vessel dimensions and force–displacement curves. Upon calibration of a first order Ogden model to fit the data, a difference was found in the μ parameter (4.43 × 10−4 ± 3.67 × 10−4 control, 7.77 × 10−4 ± 6.96 × 10−4 LPS-treated) and no difference was noted in the α parameter (12.96 ± 2.145 control, 12.65 ± 3.378 LPS-treated), although neither finding was statistically significant (p > 0.4, p > 0.8, respectively). Our preliminary ex-vivo data suggests that intra-amniotic LPS-induced systemic inflammation does not significantly change the stiffness or strength of the aorta. With further work, we hope our study can help fully elucidate the role of inflammation on aorta biomechanics.
Original languageEnglish
Title of host publicationComputational biomechanics for medicine
Subtitle of host publicationFrom algorithms to models and applications
EditorsAdam Wittek, Grand Joldes, Poul M.F. Nielsen, Barry J. Doyle, Karol Miller
PublisherSpringer International Publishing
Pages15-25
ISBN (Electronic)9783319544816
ISBN (Print)9783319544809
DOIs
Publication statusPublished - 2017
EventComputational Biomechanics for Medicine XI - Athens, Greece
Duration: 17 Oct 201621 Oct 2016
http://www.miccai2016.org/

Publication series

NameComputational Biomechanics for Medicine
PublisherSpringer International Publishing

Workshop

WorkshopComputational Biomechanics for Medicine XI
Abbreviated titleMICCAI 2016
CountryGreece
CityAthens
Period17/10/1621/10/16
Internet address

Fingerprint

Aorta
Lipopolysaccharides
Biomechanical Phenomena
Inflammation
Calibration
Blood Vessels
Sheep
Atherosclerosis
Cardiovascular Diseases
Arteries
Control Groups

Cite this

Macrae, R. A., Pillow, J., Miller, K., & Doyle, B. (2017). Constitutive modelling of lamb aorta. In A. Wittek, G. Joldes, P. M. F. Nielsen, B. J. Doyle, & K. Miller (Eds.), Computational biomechanics for medicine: From algorithms to models and applications (pp. 15-25). (Computational Biomechanics for Medicine). Springer International Publishing. https://doi.org/10.1007/978-3-319-54481-6_2
Macrae, Ryley Asher ; Pillow, Jennifer ; Miller, Karol ; Doyle, Barry. / Constitutive modelling of lamb aorta. Computational biomechanics for medicine: From algorithms to models and applications. editor / Adam Wittek ; Grand Joldes ; Poul M.F. Nielsen ; Barry J. Doyle ; Karol Miller. Springer International Publishing, 2017. pp. 15-25 (Computational Biomechanics for Medicine).
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Macrae, RA, Pillow, J, Miller, K & Doyle, B 2017, Constitutive modelling of lamb aorta. in A Wittek, G Joldes, PMF Nielsen, BJ Doyle & K Miller (eds), Computational biomechanics for medicine: From algorithms to models and applications. Computational Biomechanics for Medicine, Springer International Publishing, pp. 15-25, Computational Biomechanics for Medicine XI, Athens, Greece, 17/10/16. https://doi.org/10.1007/978-3-319-54481-6_2

Constitutive modelling of lamb aorta. / Macrae, Ryley Asher; Pillow, Jennifer; Miller, Karol; Doyle, Barry.

Computational biomechanics for medicine: From algorithms to models and applications. ed. / Adam Wittek; Grand Joldes; Poul M.F. Nielsen; Barry J. Doyle; Karol Miller. Springer International Publishing, 2017. p. 15-25 (Computational Biomechanics for Medicine).

Research output: Chapter in Book/Conference paperChapter

TY - CHAP

T1 - Constitutive modelling of lamb aorta

AU - Macrae, Ryley Asher

AU - Pillow, Jennifer

AU - Miller, Karol

AU - Doyle, Barry

PY - 2017

Y1 - 2017

N2 - Vascular inflammation is an established marker of cardiovascular pathogenesis, particularly atherosclerosis, but its role on arterial tissue biomechanics is not well understood. Its impact on the biomechanics of the aorta can yield valuable data for elucidating its role in disease formation, as well as leading to the development of valuable predictive models for surgery and new treatments. Changes in arterial biomechanics can lead to arterial remodelling and dysfunction, and so its quantification can provide insight into the nature of inflammatory processes. To gain further insight into these processes we investigated the biomechanical behaviour of lamb aortas from inflamed and control groups through the development of a constitutive model. The development of reliable constitutive models of the artery is necessary in order to fully understand the mechanical component of cardiovascular disease pathogenesis and vascular remodelling. We used a foetal sheep model of systemic inflammation induced by prenatal lipopolysaccharide (LPS) treatment (n = 6) to investigate the effects of short-term inflammation on the passive biomechanical response of the aorta. We subjected samples cut from aortas (LPS, n = 6; control, n = 4) to uniaxial tension testing until failure, measuring vessel dimensions and force–displacement curves. Upon calibration of a first order Ogden model to fit the data, a difference was found in the μ parameter (4.43 × 10−4 ± 3.67 × 10−4 control, 7.77 × 10−4 ± 6.96 × 10−4 LPS-treated) and no difference was noted in the α parameter (12.96 ± 2.145 control, 12.65 ± 3.378 LPS-treated), although neither finding was statistically significant (p > 0.4, p > 0.8, respectively). Our preliminary ex-vivo data suggests that intra-amniotic LPS-induced systemic inflammation does not significantly change the stiffness or strength of the aorta. With further work, we hope our study can help fully elucidate the role of inflammation on aorta biomechanics.

AB - Vascular inflammation is an established marker of cardiovascular pathogenesis, particularly atherosclerosis, but its role on arterial tissue biomechanics is not well understood. Its impact on the biomechanics of the aorta can yield valuable data for elucidating its role in disease formation, as well as leading to the development of valuable predictive models for surgery and new treatments. Changes in arterial biomechanics can lead to arterial remodelling and dysfunction, and so its quantification can provide insight into the nature of inflammatory processes. To gain further insight into these processes we investigated the biomechanical behaviour of lamb aortas from inflamed and control groups through the development of a constitutive model. The development of reliable constitutive models of the artery is necessary in order to fully understand the mechanical component of cardiovascular disease pathogenesis and vascular remodelling. We used a foetal sheep model of systemic inflammation induced by prenatal lipopolysaccharide (LPS) treatment (n = 6) to investigate the effects of short-term inflammation on the passive biomechanical response of the aorta. We subjected samples cut from aortas (LPS, n = 6; control, n = 4) to uniaxial tension testing until failure, measuring vessel dimensions and force–displacement curves. Upon calibration of a first order Ogden model to fit the data, a difference was found in the μ parameter (4.43 × 10−4 ± 3.67 × 10−4 control, 7.77 × 10−4 ± 6.96 × 10−4 LPS-treated) and no difference was noted in the α parameter (12.96 ± 2.145 control, 12.65 ± 3.378 LPS-treated), although neither finding was statistically significant (p > 0.4, p > 0.8, respectively). Our preliminary ex-vivo data suggests that intra-amniotic LPS-induced systemic inflammation does not significantly change the stiffness or strength of the aorta. With further work, we hope our study can help fully elucidate the role of inflammation on aorta biomechanics.

UR - http://cbm.mech.uwa.edu.au/CBM2016/

U2 - 10.1007/978-3-319-54481-6_2

DO - 10.1007/978-3-319-54481-6_2

M3 - Chapter

SN - 9783319544809

T3 - Computational Biomechanics for Medicine

SP - 15

EP - 25

BT - Computational biomechanics for medicine

A2 - Wittek, Adam

A2 - Joldes, Grand

A2 - Nielsen, Poul M.F.

A2 - Doyle, Barry J.

A2 - Miller, Karol

PB - Springer International Publishing

ER -

Macrae RA, Pillow J, Miller K, Doyle B. Constitutive modelling of lamb aorta. In Wittek A, Joldes G, Nielsen PMF, Doyle BJ, Miller K, editors, Computational biomechanics for medicine: From algorithms to models and applications. Springer International Publishing. 2017. p. 15-25. (Computational Biomechanics for Medicine). https://doi.org/10.1007/978-3-319-54481-6_2