Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes

Jean Sébastien Hulot, Francesca Stillitano, Joe Elie Salem, Jason C. Kovacic, Valentin Fuster, Roger J. Hajjar

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Pluripotent stem cells (PSCs) represent an appealing source from which to develop cell replacement therapies. Different initiatives have been launched to promote their development toward clinical applications. This article will review the main questions that should be considered before translating PSC-derived cardiomyocytes into clinical investigations, including the development of good manufacturing practice-level PSC lines, the development of efficient protocols to generate pure populations of cardiac myocytes, and the development of techniques to improve the retention and survival rate of transplanted cells.

Original languageEnglish
Article number1
JournalStem Cell Research and Therapy
Volume5
Issue number1
DOIs
Publication statusPublished - 9 Jan 2014
Externally publishedYes

Fingerprint

Dive into the research topics of 'Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes'. Together they form a unique fingerprint.

Cite this