Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014

Christopher Blyth, N.M. Gilroy, S.D. Guy, S.T. Chambers, E.Y. Cheong, T. Gottlieb, S.L. Mcguinness, K.A. Thursky

    Research output: Contribution to journalArticle

    43 Citations (Scopus)

    Abstract

    © 2014 The Authors; Internal Medicine Journal © 2014 Royal Australasian College of Physicians. Mould species represent the pathogens most commonly associated with invasive fungal disease in patients with haematological malignancies and patients of haemopoietic stem cell transplants. Invasive mould infections in these patient populations, particularly in the setting of neutropenia, are associated with high morbidity and mortality, and significantly increase the complexity of management. While Aspergillus species remain the most prevalent cause of invasive mould infections, Scedosporium and Fusarium species and the Mucormycetes continue to place a significant burden on the immunocompromised host. Evidence also suggests that infections caused by rare and emerging pathogens are increasing within the setting of broad-spectrum antifungal prophylaxis and improved survival times placing immunosuppressed patients at risk for longer. These guidelines present evidence-based recommendations for the antifungal management of common, rare and emerging mould infections in both adult and paediatric populations. Where relevant, the role of surgery, adjunctive therapy and immunotherapy is also discussed.
    Original languageEnglish
    Pages (from-to)1333-1349
    JournalInternal Medicine Journal
    Volume44
    Issue number12
    DOIs
    Publication statusPublished - 2014

    Fingerprint Dive into the research topics of 'Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014'. Together they form a unique fingerprint.

    Cite this