Connexins and diabetes

Josephine A. Wright, Toby Richards, David L. Becker

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called connexins. In this paper, we discuss current knowledge about connexins in diabetes. We also discuss mechanisms of connexin influence and the role of individual connexins in various tissues and how these are affected in diabetes. Connexins may be a future target by both genetic and pharmacological approaches to develop treatments for the treatment of diabetes and its complications.

Original languageEnglish
Article number496904
JournalCardiology Research and Practice
Volume2012
DOIs
Publication statusPublished - 19 Apr 2012
Externally publishedYes

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