Connexins and diabetes

Josephine A. Wright; Toby Richards; David L. Becker

doi:10.1155/2012/496904

Connexins and diabetes

Josephine A. Wright, Toby Richards, David L. Becker

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called connexins. In this paper, we discuss current knowledge about connexins in diabetes. We also discuss mechanisms of connexin influence and the role of individual connexins in various tissues and how these are affected in diabetes. Connexins may be a future target by both genetic and pharmacological approaches to develop treatments for the treatment of diabetes and its complications.

Original language	English
Article number	496904
Journal	Cardiology Research and Practice
Volume	2012
DOIs	https://doi.org/10.1155/2012/496904
Publication status	Published - 19 Apr 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1155/2012/496904Licence: CC BY

Cite this

@article{55421f1e0c1c40e0b76a606d4e64d849,

title = "Connexins and diabetes",

abstract = "Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called connexins. In this paper, we discuss current knowledge about connexins in diabetes. We also discuss mechanisms of connexin influence and the role of individual connexins in various tissues and how these are affected in diabetes. Connexins may be a future target by both genetic and pharmacological approaches to develop treatments for the treatment of diabetes and its complications.",

author = "Wright, {Josephine A.} and Toby Richards and Becker, {David L.}",

year = "2012",

month = apr,

day = "19",

doi = "10.1155/2012/496904",

language = "English",

volume = "2012",

journal = "Cardiology Research and Practice",

issn = "2090-8016",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Connexins and diabetes

AU - Wright, Josephine A.

AU - Richards, Toby

AU - Becker, David L.

PY - 2012/4/19

Y1 - 2012/4/19

N2 - Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called connexins. In this paper, we discuss current knowledge about connexins in diabetes. We also discuss mechanisms of connexin influence and the role of individual connexins in various tissues and how these are affected in diabetes. Connexins may be a future target by both genetic and pharmacological approaches to develop treatments for the treatment of diabetes and its complications.

AB - Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called connexins. In this paper, we discuss current knowledge about connexins in diabetes. We also discuss mechanisms of connexin influence and the role of individual connexins in various tissues and how these are affected in diabetes. Connexins may be a future target by both genetic and pharmacological approaches to develop treatments for the treatment of diabetes and its complications.

UR - http://www.scopus.com/inward/record.url?scp=84859780603&partnerID=8YFLogxK

U2 - 10.1155/2012/496904

DO - 10.1155/2012/496904

M3 - Review article

AN - SCOPUS:84859780603

SN - 2090-8016

VL - 2012

JO - Cardiology Research and Practice

JF - Cardiology Research and Practice

M1 - 496904

ER -

Connexins and diabetes

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this