TY - JOUR
T1 - Connecting Versatile lncRNAs with Heterogeneous Nuclear Ribonucleoprotein K and Pathogenic Disorders
AU - Zhu, S.
AU - Wang, Ziyi
AU - Xu, J.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA-binding protein that regulates multiple biological processes, including paraspeckles formation and cellular signal transduction. Recently, hnRNPK has been shown to interact with SINE-derived nuclear RNA localization (SIRLOIN)-containing RNAs, and orchestrate nuclear enrichment and cellular functions of long noncoding RNAs (lncRNAs). hnRNPK–lncRNAs interaction is potentially implicated in various pathogenic disorders including tumorigenesis, and Kabuki-like, Au-Kline, and Okamoto syndromes.
AB - Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA-binding protein that regulates multiple biological processes, including paraspeckles formation and cellular signal transduction. Recently, hnRNPK has been shown to interact with SINE-derived nuclear RNA localization (SIRLOIN)-containing RNAs, and orchestrate nuclear enrichment and cellular functions of long noncoding RNAs (lncRNAs). hnRNPK–lncRNAs interaction is potentially implicated in various pathogenic disorders including tumorigenesis, and Kabuki-like, Au-Kline, and Okamoto syndromes.
UR - http://www.scopus.com/inward/record.url?scp=85068211888&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2019.06.001
DO - 10.1016/j.tibs.2019.06.001
M3 - Short survey
C2 - 31279651
AN - SCOPUS:85068211888
SN - 0968-0004
VL - 44
SP - 733
EP - 736
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 9
ER -