Connecting Versatile lncRNAs with Heterogeneous Nuclear Ribonucleoprotein K and Pathogenic Disorders

S. Zhu, Ziyi Wang, J. Xu

Research output: Contribution to journalShort survey

1 Citation (Scopus)


Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA-binding protein that regulates multiple biological processes, including paraspeckles formation and cellular signal transduction. Recently, hnRNPK has been shown to interact with SINE-derived nuclear RNA localization (SIRLOIN)-containing RNAs, and orchestrate nuclear enrichment and cellular functions of long noncoding RNAs (lncRNAs). hnRNPK–lncRNAs interaction is potentially implicated in various pathogenic disorders including tumorigenesis, and Kabuki-like, Au-Kline, and Okamoto syndromes.

Original languageEnglish
Pages (from-to)733-736
Number of pages4
JournalTrends in Biochemical Sciences
Issue number9
Publication statusPublished - 1 Sep 2019


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