Projects per year
Background Conjunctival ultraviolet autofluorescence (CUVAF) is a method of detecting conjunctival damage related to ultraviolet radiation exposure. In cross-sectional studies, CUVAF area is positively associated with self-reported time spent outdoors and pterygium and negatively associated with myopia; however, longitudinal studies are scarce. Aims To use a novel deep learning-based tool to assess 8-year change in CUVAF area in young adults, investigate factors associated with this change and identify the number of new onset pterygia. Methods A deep learning-based CUVAF tool was developed to measure CUVAF area. CUVAF area and pterygium status were assessed at three study visits: baseline (participants were approximately 20 years old) and at 7-year and 8-year follow-ups. Participants self-reported sun protection behaviours and ocular history. Results CUVAF data were available for 1497 participants from at least one study visit; 633 (43%) participants had complete CUVAF data. Mean CUVAF areas at baseline and the 7-year and 8-year follow-ups were 48.4, 39.3 and 37.7 mm(2), respectively. There was a decrease in mean CUVAF area over time (change in total CUVAF area=-0.96 mm(2) per year (95% CI: -1.07 to -0.86)). For participants who wore sunglasses >= 1/2 of the time, CUVAF area decreased by an additional -0.42 mm(2) per year (95% CI: -0.72 to -0.12) on average. Fourteen (1.5%) participants developed a pterygium. Conclusions In this young adult cohort, CUVAF area declined over an 8-year period. Wearing sunglasses was associated with a faster reduction in CUVAF area. Deep learning-based models can assist in accurate and efficient measurement of CUVAF area.
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- 4 Finished
1/01/17 → 31/12/21
Eastwood, P., Mian, A., McArdle, N. & Hillman, D.
1/01/16 → 31/12/19