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Abstract
Chemical investigation of a previously unreported indigenous AustralianStreptomycesstrain MST-91080 has identified six novel analogues related to the oxazole-pendanted macrodiolide, conglobatin. Phylogenetic analysis of the 16S rRNA gene sequence identified MST-91080 as a species ofStreptomyces, distinct from reported conglobatin producer,Streptomyces conglobatusATCC 31005. Conglobatins B-E diverge from conglobatin through differing patterns of methylation on the macrodiolide skeleton. The altered methyl positions suggest a deviation from the published biosynthetic pathway, which proposed three successive methylmalonyl-CoA extender unit additions to the conglobatin monomer. Conglobatins B1, C1 and C2 exhibited more potent cytotoxic activity selectively against the NS-1 myeloma cell line (IC(50)0.084, 1.05 and 0.45 mu g ml(-1), respectively) compared with conglobatin (IC(50)1.39 mu g ml(-1)).
Original language | English |
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Pages (from-to) | 756–765 |
Number of pages | 10 |
Journal | Journal of Antibiotics |
Volume | 73 |
Issue number | 11 |
DOIs | |
Publication status | Published - 1 Nov 2020 |
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Dive into the research topics of 'Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin'. Together they form a unique fingerprint.Projects
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Uncovering the Hidden Secondary Metabolite Biosynthetic Potential of Fungi
Chooi, H. (Investigator 01)
ARC Australian Research Council
1/01/17 → 15/03/21
Project: Research