Abstract
OBJECTIVE: To review temporal changes in perinatal management and one-year survival outcomes of cases of congenital diaphragmatic hernia (CDH) from 1996-2015 in Western Australia (WA).
METHOD: Retrospective study of all cases of CDH in WA from 1996 to 2015, identified from 5 independent databases within the WA health network. Detailed information pertaining to pregnancy and survival outcomes were obtained from review of maternal and infant medical records.
RESULTS: There were 215 cases of CDH with 164 diagnosed prenatally. Between 1996-2010, a decline in livebirth rates for CDH-affected pregnancies was observed, reaching a nadir of 5.3 per 10,000 births, before increasing to a peak of 9.73 per 10,000 births in 2011-2015. A corresponding decline was seen in the number of pregnancies terminated in the same period, from 8.3 to 4.6 per 10,000 births (P = .14) and an increase in survival of livebirths, from 38.9% to 81.3% (P = 0.01).
CONCLUSION: The improved overall survival rate in infants with CDH over the last 20 years may have resulted in an increased tendency for women to continue their pregnancy with a concomitant decline in termination rates. Information from this study will help in the counselling of women following prenatal detection of CDH.
| Original language | English |
|---|---|
| Pages (from-to) | 1004-1012 |
| Journal | Prenatal Diagnosis |
| Volume | 38 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - Dec 2018 |
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Congenital diaphragmatic hernia : Impact of contemporary management strategies on perinatal outcomes. / Lee, Han-Shin; Dickinson, Jan E; Tan, Jason; Nembhard, Wendy; Bower, Carol.
In: Prenatal Diagnosis, Vol. 38, No. 13, 12.2018, p. 1004-1012.Research output: Contribution to journal › Article
TY - JOUR
T1 - Congenital diaphragmatic hernia
T2 - Impact of contemporary management strategies on perinatal outcomes
AU - Lee, Han-Shin
AU - Dickinson, Jan E
AU - Tan, Jason
AU - Nembhard, Wendy
AU - Bower, Carol
N1 - This article is protected by copyright. All rights reserved.
PY - 2018/12
Y1 - 2018/12
N2 - OBJECTIVE: To review temporal changes in perinatal management and one-year survival outcomes of cases of congenital diaphragmatic hernia (CDH) from 1996-2015 in Western Australia (WA).METHOD: Retrospective study of all cases of CDH in WA from 1996 to 2015, identified from 5 independent databases within the WA health network. Detailed information pertaining to pregnancy and survival outcomes were obtained from review of maternal and infant medical records.RESULTS: There were 215 cases of CDH with 164 diagnosed prenatally. Between 1996-2010, a decline in livebirth rates for CDH-affected pregnancies was observed, reaching a nadir of 5.3 per 10,000 births, before increasing to a peak of 9.73 per 10,000 births in 2011-2015. A corresponding decline was seen in the number of pregnancies terminated in the same period, from 8.3 to 4.6 per 10,000 births (P = .14) and an increase in survival of livebirths, from 38.9% to 81.3% (P = 0.01).CONCLUSION: The improved overall survival rate in infants with CDH over the last 20 years may have resulted in an increased tendency for women to continue their pregnancy with a concomitant decline in termination rates. Information from this study will help in the counselling of women following prenatal detection of CDH.
AB - OBJECTIVE: To review temporal changes in perinatal management and one-year survival outcomes of cases of congenital diaphragmatic hernia (CDH) from 1996-2015 in Western Australia (WA).METHOD: Retrospective study of all cases of CDH in WA from 1996 to 2015, identified from 5 independent databases within the WA health network. Detailed information pertaining to pregnancy and survival outcomes were obtained from review of maternal and infant medical records.RESULTS: There were 215 cases of CDH with 164 diagnosed prenatally. Between 1996-2010, a decline in livebirth rates for CDH-affected pregnancies was observed, reaching a nadir of 5.3 per 10,000 births, before increasing to a peak of 9.73 per 10,000 births in 2011-2015. A corresponding decline was seen in the number of pregnancies terminated in the same period, from 8.3 to 4.6 per 10,000 births (P = .14) and an increase in survival of livebirths, from 38.9% to 81.3% (P = 0.01).CONCLUSION: The improved overall survival rate in infants with CDH over the last 20 years may have resulted in an increased tendency for women to continue their pregnancy with a concomitant decline in termination rates. Information from this study will help in the counselling of women following prenatal detection of CDH.
UR - https://www-scopus-com.ezproxy.library.uwa.edu.au/record/display.uri?eid=2-s2.0-85056206971&origin=resultslist&sort=plf-f&src=s&st1=Congenital+diaphragmatic+hernia%3a+Impact+of+contemporary+management+strategies+on+perinatal+outcomes&st2=&sid=633915aff80d7d38dbeb1cd129cc6903&sot=b&sdt=b&sl=114&s=TITLE-ABS-KEY%28Congenital+diaphragmatic+hernia%3a+Impact+of+contemporary+management+strategies+on+perinatal+outcomes%29&relpos=0&citeCnt=0&searchTerm=
U2 - 10.1002/pd.5376
DO - 10.1002/pd.5376
M3 - Article
VL - 38
SP - 1004
EP - 1012
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
SN - 0197-3851
IS - 13
ER -