COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults

Tenielle Porter, Samantha C. Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Hamid R. Sohrabi, Madeline Peretti, Yen Ying Lim, Michael Weinborn, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L. Villemagne, Simon M. Laws

Research output: Contribution to journalArticle

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Abstract

The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer's disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or interactional associations between COMT Val158Met and cognitive decline. These findings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not influence Aβ-amyloid or APOE ε4 driven cognitive decline in a well characterised cohort of cognitively normal older adults.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalIBRO Reports
Volume6
DOIs
Publication statusPublished - 1 Jun 2019

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Apolipoprotein E4
Catechol O-Methyltransferase
Amyloid
Cognition
Single Nucleotide Polymorphism
Alzheimer Disease
Alleles
Cognitive Dysfunction
Genes

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Porter, T., Burnham, S. C., Milicic, L., Savage, G., Maruff, P., Sohrabi, H. R., ... Laws, S. M. (2019). COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6, 147-152. https://doi.org/10.1016/j.ibror.2019.05.001
Porter, Tenielle ; Burnham, Samantha C. ; Milicic, Lidija ; Savage, Greg ; Maruff, Paul ; Sohrabi, Hamid R. ; Peretti, Madeline ; Lim, Yen Ying ; Weinborn, Michael ; Ames, David ; Masters, Colin L. ; Martins, Ralph N. ; Rainey-Smith, Stephanie ; Rowe, Christopher C. ; Salvado, Olivier ; Groth, David ; Verdile, Giuseppe ; Villemagne, Victor L. ; Laws, Simon M. / COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. In: IBRO Reports. 2019 ; Vol. 6. pp. 147-152.
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abstract = "The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer's disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or interactional associations between COMT Val158Met and cognitive decline. These findings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not influence Aβ-amyloid or APOE ε4 driven cognitive decline in a well characterised cohort of cognitively normal older adults.",
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Porter, T, Burnham, SC, Milicic, L, Savage, G, Maruff, P, Sohrabi, HR, Peretti, M, Lim, YY, Weinborn, M, Ames, D, Masters, CL, Martins, RN, Rainey-Smith, S, Rowe, CC, Salvado, O, Groth, D, Verdile, G, Villemagne, VL & Laws, SM 2019, 'COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults' IBRO Reports, vol. 6, pp. 147-152. https://doi.org/10.1016/j.ibror.2019.05.001

COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. / Porter, Tenielle; Burnham, Samantha C.; Milicic, Lidija; Savage, Greg; Maruff, Paul; Sohrabi, Hamid R.; Peretti, Madeline; Lim, Yen Ying; Weinborn, Michael; Ames, David; Masters, Colin L.; Martins, Ralph N.; Rainey-Smith, Stephanie; Rowe, Christopher C.; Salvado, Olivier; Groth, David; Verdile, Giuseppe; Villemagne, Victor L.; Laws, Simon M.

In: IBRO Reports, Vol. 6, 01.06.2019, p. 147-152.

Research output: Contribution to journalArticle

TY - JOUR

T1 - COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults

AU - Porter, Tenielle

AU - Burnham, Samantha C.

AU - Milicic, Lidija

AU - Savage, Greg

AU - Maruff, Paul

AU - Sohrabi, Hamid R.

AU - Peretti, Madeline

AU - Lim, Yen Ying

AU - Weinborn, Michael

AU - Ames, David

AU - Masters, Colin L.

AU - Martins, Ralph N.

AU - Rainey-Smith, Stephanie

AU - Rowe, Christopher C.

AU - Salvado, Olivier

AU - Groth, David

AU - Verdile, Giuseppe

AU - Villemagne, Victor L.

AU - Laws, Simon M.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer's disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or interactional associations between COMT Val158Met and cognitive decline. These findings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not influence Aβ-amyloid or APOE ε4 driven cognitive decline in a well characterised cohort of cognitively normal older adults.

AB - The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer's disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or interactional associations between COMT Val158Met and cognitive decline. These findings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not influence Aβ-amyloid or APOE ε4 driven cognitive decline in a well characterised cohort of cognitively normal older adults.

KW - Aβ-amyloid

KW - Catechol-O-methyltransferase

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KW - COMT

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U2 - 10.1016/j.ibror.2019.05.001

DO - 10.1016/j.ibror.2019.05.001

M3 - Article

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EP - 152

JO - IBRO Reports

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