Computer Simulation of Resection-Induced Brain Shift

Yue Yu

Research output: ThesisDoctoral Thesis

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This thesis describes a biomechanics-based image registration method that compensates for the tumour resection-induced brain shift during neurosurgery. Initially, I used the finite element method (FEM) to compute the resection-induced brain deformation. However, using FEM to compute soft tissue deformations comes with a number of limitations, such as volumetric locking and time-consuming mesh generation. To circumvent these limitations, I used the Meshless Total Lagrangian Explicit Dynamics algorithm to compute the resection-induced brain deformation. Finally, I demonstrated how the modelling process can be automated to facilitate image-guided neurosurgery. To validate the methodology, I compared the results with the retrospective clinical data.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
  • Miller, Karol, Supervisor
  • Wittek, Adam, Supervisor
Thesis sponsors
Award date11 Jul 2022
Publication statusUnpublished - 2022


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