Computational model for the analysis of cartilage and cartilage tissue constructs

David Smith, Bruce Gardiner, John Davidson, A.J. Grodzinsky

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    We propose a new non-linear poroelastic model that is suited to the analysis of soft tissues. In this paper the model is tailored to the analysis of cartilage and the engineering design of cartilage constructs. The proposed continuum formulation of the governing equations enables the strain of the individual material components within the extracellular matrix (ECM) to be followed over time, as the individual material components are synthesized, assembled and incorporated within the ECM or lost through passive transport or degradation. The material component analysis developed here naturally captures the effect of time-dependent changes of ECM composition on the deformation and internal stress states of the ECM. For example, it is shown that increased synthesis of aggrecan by chondrocytes embedded within a decellularized cartilage matrix initially devoid of aggrecan results in osmotic expansion of the newly synthesized proteoglycan matrix and tension within the structural collagen network. Specifically, we predict that the collagen network experiences a tensile strain, with a maximum of ~2% at the fixed base of the cartilage. The analysis of an example problem demonstrates the temporal and spatial evolution of the stresses and strains in each component of a self-equilibrating composite tissue construct, and the role played by the flux of water through the tissue. Copyright © 2013 John Wiley & Sons, Ltd.
    Original languageEnglish
    Pages (from-to)334-347
    Number of pages14
    JournalJournal of Tissue Engineering and Regenerative Medicine
    Volume10
    Issue number4
    Early online date20 Jun 2013
    DOIs
    Publication statusPublished - 7 Apr 2016

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