Comprehensive Assessment of the Hemostatic System in Polycystic Ovarian Syndrome

Genia Burchall, Terrence Piva, Matthew Linden, Melanie Gibson-Helm, Sanjeeva Ranasinha, Helena Teede

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)

Abstract

Polycystic ovarian syndrome (PCOS) affects 12 to 19% of women and has reproductive and metabolic features (endothelial dysfunction, increased diabetes, and cardiovascular risk factors). It also appears to have altered coagulation and fibrinolysis with a prothrombotic state with epidemiological evidence of increased venous thromboembolism. We aimed to comprehensively assess hemostasis in women with PCOS versus control women. In an established case–control cohort of lean, overweight, and obese women with (n ¼ 107) and without PCOS (n ¼ 67), with existing measures of plasminogen activator inhibitor 1 (PAI-1), asymmetric dimethylarginine (ADMA), hormonal, and metabolic markers, we also assessed prothrombin fragments 1 and 2 (PF1 & 2), plasminogen, tissue plasminogen activator (tPA), and thrombin generation (TG). Higher levels of ADMA (0.70 vs. 0.39 µmol/L, p < 0.01), PAI-1 (4.80 vs. 3.66 U/mL, p < 0.01), and plasminogen (118.39 vs. 108.46%, p < 0.01) were seen in PCOS versus controls, and persisted after adjustment for age and body mass index (BMI). PF1 & 2 was marginally lower (180.0 vs. 236.0 pmol/L, p ¼ 0.05), whereas tPA and TG were not different between groups, after adjustment for age and BMI. Significant relationships were observed between hormonal and metabolic factors with ADMA and PAI-1. We demonstrate impaired fibrinolysis in PCOS. In the context of abnormal endothelial function and known hormonal and metabolic abnormalities, this finding may underpin an increased risk of cardiovascular disease and venous thrombosis in PCOS.
Original languageEnglish
Pages (from-to)55-62
JournalSeminars in Thrombosis and Hemostasis
Volume42
Issue number1
DOIs
Publication statusPublished - 2015

Fingerprint

Dive into the research topics of 'Comprehensive Assessment of the Hemostatic System in Polycystic Ovarian Syndrome'. Together they form a unique fingerprint.

Cite this