Comprehensive analysis of damage associated SNPs of MMP9 gene: A computational approach

Richa Bhatnager, Maheshwar Bhasin, Amita S Dang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Extracellular matrix is a dynamic meshwork of macromolecules that plays an important role in biological processes such as tissue remodeling and various developmental processes. Collagen is the chief component of ECM. Upon hydrolysis, it forms an irreversible left-handed helical structure which is further hydrolyzed by a specialized group of MMP family i.e. Gelatinases (MMP2 and MMP9). Present study was carried to figure out deleterious SNPs associated with MMP9 gene. Our results showed that two nsSNP (rs8125581 and rs41529445) that are present in catalytic domain are highly conserved and affect the protein structure and function.7 SNPs located in UTRs were found to alter miRNA seed region 13 SNPs of splice site were predicted to affect splice signals thereby affecting the post translational expression of MMP9. Most of the SNPs are still uncharacterized thereby present study provides a direction that can help to validate the relation between the altered expressions and functions of MMP9 protein in terms of disease susceptibility.

Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalComputational Biology and Chemistry
Volume77
DOIs
Publication statusPublished - Dec 2018
Externally publishedYes

Fingerprint

Dive into the research topics of 'Comprehensive analysis of damage associated SNPs of MMP9 gene: A computational approach'. Together they form a unique fingerprint.

Cite this