Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals

Alex De Mendoza, H. Suga, J. Permanyer, M. Irimia, I. Ruiz-Trillo

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

© 2015, © Mendoza et al. Cell-type specification through differential genome regulation is a hallmark of complex multicellularity. However, it remains unclear how this process evolved during the transition from unicellular to multicellular organisms. To address this question, we investigated transcriptional dynamics in the ichthyosporean Creolimax fragrantissima, a relative of animals that undergoes coenocytic development. We find that Creolimax utilizes dynamic regulation of alternative splicing, long inter-genic non-coding RNAs and co-regulated gene modules associated with animal multicellularity in a cell-type specific manner. Moreover, our study suggests that the different cell types of the three closest animal relatives (ichthyosporeans, filastereans and choanoflagellates) are the product of lineage-specific innovations. Additionally, a proteomic survey of the secretome reveals adaptations to a fungal-like lifestyle. In summary, the diversity of cell types among protistan relatives of animals and their complex genome regulation demonstrates that the last unicellular ancestor of animals was already capable of elaborate specification of cell types.
Original languageEnglish
Pages (from-to)e08904
JournaleLife
Volume4
Issue numberOCTOBER2015
DOIs
Publication statusPublished - 2015

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