TY - JOUR
T1 - Complement-Mediated Regulation of Trichomonas vaginalis Infection in Mice
AU - Caterina, P.
AU - Lynch, D.
AU - Ashman, R.B.
AU - Warton, A.
AU - Papadimitriou, John
PY - 1999
Y1 - 1999
N2 - Trichomonas vaginalis is a flagellated protozoan which causes trichomoniasis, a sexually transmitted disease of the human genitourinary tract, The importance of the alternative complement pathway in host defence against T. vaginalis was investigated in vitro. Kinetic studies utilising immunofixation following electrophoresis showed that both a strongly and weakly virulent strain of T, vaginalis activated murine serum C3. In vivo studies with congenic-resistant, C5-deficient, B10.D2/OSn- and C5-sufficient, B10.D2/nSn mice showed that the presence of C5 is a significant factor in the innate host resistance to primary infection with a strongly virulent, but not a weakly virulent trichomonad strain.
AB - Trichomonas vaginalis is a flagellated protozoan which causes trichomoniasis, a sexually transmitted disease of the human genitourinary tract, The importance of the alternative complement pathway in host defence against T. vaginalis was investigated in vitro. Kinetic studies utilising immunofixation following electrophoresis showed that both a strongly and weakly virulent strain of T, vaginalis activated murine serum C3. In vivo studies with congenic-resistant, C5-deficient, B10.D2/OSn- and C5-sufficient, B10.D2/nSn mice showed that the presence of C5 is a significant factor in the innate host resistance to primary infection with a strongly virulent, but not a weakly virulent trichomonad strain.
UR - https://www.scopus.com/pages/publications/0032935378
U2 - 10.1159/000019101
DO - 10.1159/000019101
M3 - Article
SN - 0254-9670
VL - 16
SP - 107
EP - 116
JO - Experimental and Clinical Immunogenetics
JF - Experimental and Clinical Immunogenetics
IS - N/A
ER -