Comparitive proteomic analysis of nonmalignant and early stage prostate cancers

Katie Meehan

    Research output: ThesisDoctoral Thesis

    198 Downloads (Pure)


    [Truncated] Prostate cancer is the most common cause of non-cutaneous malignancy in men and although frequently latent, is the second commonest cause of cancer deaths. The aetiology of prostate cancer is largely undefined as are protein and genetic alterations characteristic of early stage prostate cancers. Using proteomics, this study mapped and compared the protein profiles of nonmalignant and malignant prostate tissues with the primary aim of identifying proteins that may be involved in the development of early stage prostate cancers. In total, 57 proteins with reduced levels in malignant compared to nonmalignant tissues were selected and 23 were conclusively identified using mass spectrometry and protein sequencing. In addition, 69 proteins with increased levels in malignant tissues were selected. Of the 23 proteins identified, 7 were examined further using one- and two- dimensional western blotting and immunohistochemistry to characterise protein forms present within tissues and cellular distribution of individual proteins.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Publication statusUnpublished - 2002

    Take-down notice

    • This thesis has been made available in the UWA Profiles and Research Repository as part of a UWA Library project to digitise and make available theses completed before 2003. If you are the author of this thesis and would like it removed from the UWA Profiles and Research Repository, please contact


    Dive into the research topics of 'Comparitive proteomic analysis of nonmalignant and early stage prostate cancers'. Together they form a unique fingerprint.

    Cite this