Comparison of residual depressive symptoms and functional impairment between fully and partially remitted patients with major depressive disorder: a multicenter study

Le Xiao, Lei Feng, Xue quan Zhu, Yuan Feng, Wen yuan Wu, Gabor S. Ungvari, Chee H. Ng, Yu Tao Xiang, Gang Wang

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Abstract

This study compared residual depressive and somatic symptoms and functional impairment between remitted and partially remitted patients with major depressive disorder (MDD), and explored the associations of functioning with demographic and clinical characteristics including residual depressive symptoms. Altogether, 1503 outpatients with MDD formed the study sample. Residual symptoms and psychosocial functioning were measured using standardized instruments. Approximately half (51.2%) of the patients who responded to antidepressant treatment achieved remission (‘remitters’), while the rest who responded to treatment achieved only partial remission (’non-remitters’). Residual mood symptoms in remitters included sleep disturbances (66.6%), fatigue (32.3%), decreased concentration (31.3%), appetite/weight disturbances (28.8%), psychomotor changes (23.2%), sad mood (21.9%) and loss of interest (21.1%) measured by the Quick Inventory of Depressive Symptomatology-Self-Report. Residual somatic symptoms included headache (31.9%), intestinal complaints (31.3%), heart pounding/racing (26.3%), gastric complaints (22.3%), dizziness (22.2%) and stomach pain (20.6%) measured by the Patient Health Questionnaire-15. Such residual symptoms were even more frequent in the ‘non-remitters’ group. Residual symptoms of fatigue, psychomotor changes, sleep disturbance and appetite/weight disturbance contributed to impairment of all functional domains. Given the negative impact of residual symptoms on psychosocial functioning, more attention needs to be paid to the assessment and treatment of residual depressive symptoms.

Original languageEnglish
Pages (from-to)547-553
Number of pages7
JournalPsychiatry Research
Volume261
DOIs
Publication statusPublished - 1 Mar 2018

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Major Depressive Disorder
Multicenter Studies
Appetite
Depression
Fatigue
Stomach
Sleep
Weights and Measures
Dizziness
Self Report
Antidepressive Agents
Headache
Outpatients
Therapeutics
Demography
Pain
Equipment and Supplies
Health
Medically Unexplained Symptoms

Cite this

Xiao, Le ; Feng, Lei ; Zhu, Xue quan ; Feng, Yuan ; Wu, Wen yuan ; Ungvari, Gabor S. ; Ng, Chee H. ; Xiang, Yu Tao ; Wang, Gang. / Comparison of residual depressive symptoms and functional impairment between fully and partially remitted patients with major depressive disorder : a multicenter study. In: Psychiatry Research. 2018 ; Vol. 261. pp. 547-553.
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abstract = "This study compared residual depressive and somatic symptoms and functional impairment between remitted and partially remitted patients with major depressive disorder (MDD), and explored the associations of functioning with demographic and clinical characteristics including residual depressive symptoms. Altogether, 1503 outpatients with MDD formed the study sample. Residual symptoms and psychosocial functioning were measured using standardized instruments. Approximately half (51.2{\%}) of the patients who responded to antidepressant treatment achieved remission (‘remitters’), while the rest who responded to treatment achieved only partial remission (’non-remitters’). Residual mood symptoms in remitters included sleep disturbances (66.6{\%}), fatigue (32.3{\%}), decreased concentration (31.3{\%}), appetite/weight disturbances (28.8{\%}), psychomotor changes (23.2{\%}), sad mood (21.9{\%}) and loss of interest (21.1{\%}) measured by the Quick Inventory of Depressive Symptomatology-Self-Report. Residual somatic symptoms included headache (31.9{\%}), intestinal complaints (31.3{\%}), heart pounding/racing (26.3{\%}), gastric complaints (22.3{\%}), dizziness (22.2{\%}) and stomach pain (20.6{\%}) measured by the Patient Health Questionnaire-15. Such residual symptoms were even more frequent in the ‘non-remitters’ group. Residual symptoms of fatigue, psychomotor changes, sleep disturbance and appetite/weight disturbance contributed to impairment of all functional domains. Given the negative impact of residual symptoms on psychosocial functioning, more attention needs to be paid to the assessment and treatment of residual depressive symptoms.",
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Comparison of residual depressive symptoms and functional impairment between fully and partially remitted patients with major depressive disorder : a multicenter study. / Xiao, Le; Feng, Lei; Zhu, Xue quan; Feng, Yuan; Wu, Wen yuan; Ungvari, Gabor S.; Ng, Chee H.; Xiang, Yu Tao; Wang, Gang.

In: Psychiatry Research, Vol. 261, 01.03.2018, p. 547-553.

Research output: Contribution to journalArticle

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