Comparison of QCT-derived and DXA-derived areal bone mineral density and T scores

B.C.C. Khoo, K. Brown, C. Cann, Kun Zhu, S. Henzell, V.H.S. Low, S. Gustafsson, R.I. Price, Richard Prince

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    131 Citations (Scopus)


    Two-dimensional areal bone mineral density (aBMD) of the proximal femur measured by three-dimensional quantitative computed tomography (QCT) in 91 elderly women was compared to dual-energy X-ray absorptiometry (DXA) aBMD results measured in the same patients. The measurements were highly correlated, though QCT aBMD values were marginally lower in absolute units. Transformation of the QCT aBMD values to T score values using National Health and Nutrition Examination Survey (NHANES) DXA-derived reference data improved agreement and clinical utility.IntroductionWorld Health Organization guidelines promulgate aBMD (g cm−2) measurement of the proximal femur for the diagnosis of bone fragility. In recent years, there has been increasing interest in QCT to facilitate understanding of three-dimensional bone structure and strength.ObjectiveTo assist in comparison of QCT-derived data with DXA aBMD results, a technique for deriving aBMD from QCT measurements has been developed.MethodsTo test the validity of the QCT method, 91 elderly females were scanned on both DXA and CT scanners. QCT-derived DXA equivalent aBMD (QCTDXA aBMD) was calculated using CTXA Hip™ software (Mindways Software Inc., Austin, TX, USA) and compared to DXA-derived aBMD results.ResultsTest retest analysis indicated lower root mean square (RMS) errors for CTXA; F test between CTXA and DXA was significantly different at femoral neck (FN) and trochanter (TR) (p 
    Original languageEnglish
    Pages (from-to)1539-1545
    JournalOsteoporosis International
    Issue number9
    Publication statusPublished - 2009


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