Comparison of multiple sclerosis patients with and without oligoclonal IgG bands in South China

Tingting Lu, Lin Zhao, Xiaobo Sun, Cheryl Au, Yinong Huang, Yu Yang, Jian Bao, Aimin Wu, Allan G. Kermode, Wei Qiu, Alexander Y. Lau

    Research output: Contribution to journalArticle

    Abstract

    The data for oligoclonal IgG bands (OCB) in cerebrospinal fluid and the association with clinical profiles of Chinese patients with multiple sclerosis (MS) is lacking. We aimed to investigate the positive OCB incidence, as well as the clinical and magnetic resonance imaging (MRI) features associated with positive OCB in MS patients in South China. Consecutive MS patients were recruited from two centers, located in Guangzhou city and Hong Kong in South China. MS was re-diagnosed by McDonald criteria 2017. OCB was tested using isoelectric focusing method. The difference in the clinical and MRI features between OCB-positive and OCB-negative MS patients was evaluated. Among 184 MS patients analyzed (102 from Guangzhou and 82 from Hong Kong), 110 (59.8%) patients were OCB-positive. Except for onset age (P = 0.019), there was no significant difference between MS patients with or without OCB in relation to the course of disease, symptoms of first attack, lesion distribution on MRI, relapse rates, or disability progression. Our results demonstrate no significant clinical differences between the OCB positive and negative MS patients in this MS cohort. Larger cohort in Chinese patients with MS is warranted.

    Original languageEnglish
    Pages (from-to)51-55
    Number of pages5
    JournalJournal of Clinical Neuroscience
    Volume66
    DOIs
    Publication statusPublished - 1 Aug 2019

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    Oligoclonal Bands
    Multiple Sclerosis
    China
    Magnetic Resonance Imaging
    Hong Kong

    Cite this

    Lu, Tingting ; Zhao, Lin ; Sun, Xiaobo ; Au, Cheryl ; Huang, Yinong ; Yang, Yu ; Bao, Jian ; Wu, Aimin ; Kermode, Allan G. ; Qiu, Wei ; Lau, Alexander Y. / Comparison of multiple sclerosis patients with and without oligoclonal IgG bands in South China. In: Journal of Clinical Neuroscience. 2019 ; Vol. 66. pp. 51-55.
    @article{4334bbc8aef84143a50b4490ca5b2627,
    title = "Comparison of multiple sclerosis patients with and without oligoclonal IgG bands in South China",
    abstract = "The data for oligoclonal IgG bands (OCB) in cerebrospinal fluid and the association with clinical profiles of Chinese patients with multiple sclerosis (MS) is lacking. We aimed to investigate the positive OCB incidence, as well as the clinical and magnetic resonance imaging (MRI) features associated with positive OCB in MS patients in South China. Consecutive MS patients were recruited from two centers, located in Guangzhou city and Hong Kong in South China. MS was re-diagnosed by McDonald criteria 2017. OCB was tested using isoelectric focusing method. The difference in the clinical and MRI features between OCB-positive and OCB-negative MS patients was evaluated. Among 184 MS patients analyzed (102 from Guangzhou and 82 from Hong Kong), 110 (59.8{\%}) patients were OCB-positive. Except for onset age (P = 0.019), there was no significant difference between MS patients with or without OCB in relation to the course of disease, symptoms of first attack, lesion distribution on MRI, relapse rates, or disability progression. Our results demonstrate no significant clinical differences between the OCB positive and negative MS patients in this MS cohort. Larger cohort in Chinese patients with MS is warranted.",
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    author = "Tingting Lu and Lin Zhao and Xiaobo Sun and Cheryl Au and Yinong Huang and Yu Yang and Jian Bao and Aimin Wu and Kermode, {Allan G.} and Wei Qiu and Lau, {Alexander Y.}",
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    Comparison of multiple sclerosis patients with and without oligoclonal IgG bands in South China. / Lu, Tingting; Zhao, Lin; Sun, Xiaobo; Au, Cheryl; Huang, Yinong; Yang, Yu; Bao, Jian; Wu, Aimin; Kermode, Allan G.; Qiu, Wei; Lau, Alexander Y.

    In: Journal of Clinical Neuroscience, Vol. 66, 01.08.2019, p. 51-55.

    Research output: Contribution to journalArticle

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    AU - Lu, Tingting

    AU - Zhao, Lin

    AU - Sun, Xiaobo

    AU - Au, Cheryl

    AU - Huang, Yinong

    AU - Yang, Yu

    AU - Bao, Jian

    AU - Wu, Aimin

    AU - Kermode, Allan G.

    AU - Qiu, Wei

    AU - Lau, Alexander Y.

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    N2 - The data for oligoclonal IgG bands (OCB) in cerebrospinal fluid and the association with clinical profiles of Chinese patients with multiple sclerosis (MS) is lacking. We aimed to investigate the positive OCB incidence, as well as the clinical and magnetic resonance imaging (MRI) features associated with positive OCB in MS patients in South China. Consecutive MS patients were recruited from two centers, located in Guangzhou city and Hong Kong in South China. MS was re-diagnosed by McDonald criteria 2017. OCB was tested using isoelectric focusing method. The difference in the clinical and MRI features between OCB-positive and OCB-negative MS patients was evaluated. Among 184 MS patients analyzed (102 from Guangzhou and 82 from Hong Kong), 110 (59.8%) patients were OCB-positive. Except for onset age (P = 0.019), there was no significant difference between MS patients with or without OCB in relation to the course of disease, symptoms of first attack, lesion distribution on MRI, relapse rates, or disability progression. Our results demonstrate no significant clinical differences between the OCB positive and negative MS patients in this MS cohort. Larger cohort in Chinese patients with MS is warranted.

    AB - The data for oligoclonal IgG bands (OCB) in cerebrospinal fluid and the association with clinical profiles of Chinese patients with multiple sclerosis (MS) is lacking. We aimed to investigate the positive OCB incidence, as well as the clinical and magnetic resonance imaging (MRI) features associated with positive OCB in MS patients in South China. Consecutive MS patients were recruited from two centers, located in Guangzhou city and Hong Kong in South China. MS was re-diagnosed by McDonald criteria 2017. OCB was tested using isoelectric focusing method. The difference in the clinical and MRI features between OCB-positive and OCB-negative MS patients was evaluated. Among 184 MS patients analyzed (102 from Guangzhou and 82 from Hong Kong), 110 (59.8%) patients were OCB-positive. Except for onset age (P = 0.019), there was no significant difference between MS patients with or without OCB in relation to the course of disease, symptoms of first attack, lesion distribution on MRI, relapse rates, or disability progression. Our results demonstrate no significant clinical differences between the OCB positive and negative MS patients in this MS cohort. Larger cohort in Chinese patients with MS is warranted.

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