Comparison of comorbid depression between irritable bowel syndrome and inflammatory bowel disease: A meta-analysis of comparative studies

Qin Geng, Qing E. Zhang, Fei Wang, Wei Zheng, Chee H. Ng, Gabor S. Ungvari, Gang Wang, Yu Tao Xiang

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3 Citations (Scopus)

Abstract

Background: The prevalence of comorbid depression is high in chronic gastrointestinal disorders, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). For these two disorders in particular, the findings have not been consistent. This meta-analysis systematically compares the rates and severity of comorbid depression between IBS and IBD patients. Methods: A systematic literature search was conducted using PubMed, PsycINFO, Embase, Cochrane Library, Wan Fang, SinoMed, Chinese National Knowledge Infrastructure from their inception date to September 12, 2017 for comparative studies on IBS and IBD patients. Standardized mean differences (SMDs) and odds ratios (OR) of comorbid depression were calculated using random effect models. Data on comorbid anxiety in the included studies were also extracted and analyzed. Results: Altogether, 22 studies with 1,244 IBS and 1,048 IBD patients were included. While there was no significant group difference in the prevalence of depression (10 studies, OR = 1.18, 95%CI: 0.87–1.60, P = 0.29), the IBS group had more severe depression (pooled SMD = 0.18, 95%CI: 0.04–0.33, P = 0.01) and anxiety than the IBD group (pooled SMD = 0.31, 95%CI: 0.14–0.49, P = 0.0006). Sixteen (72.7%) studies were assessed as ‘high quality’ using the Newcastle–Ottawa Scale (NOS). Conclusions: Although the prevalence of comorbid depression was similar between groups, IBS patients had more severe comorbid depressive and anxiety symptoms compared to IBD patients. Appropriate assessment and treatment of depressive and anxiety symptoms in these patient groups should be implemented.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalJournal of Affective Disorders
Volume237
DOIs
Publication statusPublished - 1 Sep 2018

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Irritable Bowel Syndrome
Inflammatory Bowel Diseases
Meta-Analysis
Depression
Anxiety
Odds Ratio
PubMed
Crohn Disease
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Geng, Qin ; Zhang, Qing E. ; Wang, Fei ; Zheng, Wei ; Ng, Chee H. ; Ungvari, Gabor S. ; Wang, Gang ; Xiang, Yu Tao. / Comparison of comorbid depression between irritable bowel syndrome and inflammatory bowel disease : A meta-analysis of comparative studies. In: Journal of Affective Disorders. 2018 ; Vol. 237. pp. 37-46.
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abstract = "Background: The prevalence of comorbid depression is high in chronic gastrointestinal disorders, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). For these two disorders in particular, the findings have not been consistent. This meta-analysis systematically compares the rates and severity of comorbid depression between IBS and IBD patients. Methods: A systematic literature search was conducted using PubMed, PsycINFO, Embase, Cochrane Library, Wan Fang, SinoMed, Chinese National Knowledge Infrastructure from their inception date to September 12, 2017 for comparative studies on IBS and IBD patients. Standardized mean differences (SMDs) and odds ratios (OR) of comorbid depression were calculated using random effect models. Data on comorbid anxiety in the included studies were also extracted and analyzed. Results: Altogether, 22 studies with 1,244 IBS and 1,048 IBD patients were included. While there was no significant group difference in the prevalence of depression (10 studies, OR = 1.18, 95{\%}CI: 0.87–1.60, P = 0.29), the IBS group had more severe depression (pooled SMD = 0.18, 95{\%}CI: 0.04–0.33, P = 0.01) and anxiety than the IBD group (pooled SMD = 0.31, 95{\%}CI: 0.14–0.49, P = 0.0006). Sixteen (72.7{\%}) studies were assessed as ‘high quality’ using the Newcastle–Ottawa Scale (NOS). Conclusions: Although the prevalence of comorbid depression was similar between groups, IBS patients had more severe comorbid depressive and anxiety symptoms compared to IBD patients. Appropriate assessment and treatment of depressive and anxiety symptoms in these patient groups should be implemented.",
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Comparison of comorbid depression between irritable bowel syndrome and inflammatory bowel disease : A meta-analysis of comparative studies. / Geng, Qin; Zhang, Qing E.; Wang, Fei; Zheng, Wei; Ng, Chee H.; Ungvari, Gabor S.; Wang, Gang; Xiang, Yu Tao.

In: Journal of Affective Disorders, Vol. 237, 01.09.2018, p. 37-46.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of comorbid depression between irritable bowel syndrome and inflammatory bowel disease

T2 - A meta-analysis of comparative studies

AU - Geng, Qin

AU - Zhang, Qing E.

AU - Wang, Fei

AU - Zheng, Wei

AU - Ng, Chee H.

AU - Ungvari, Gabor S.

AU - Wang, Gang

AU - Xiang, Yu Tao

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: The prevalence of comorbid depression is high in chronic gastrointestinal disorders, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). For these two disorders in particular, the findings have not been consistent. This meta-analysis systematically compares the rates and severity of comorbid depression between IBS and IBD patients. Methods: A systematic literature search was conducted using PubMed, PsycINFO, Embase, Cochrane Library, Wan Fang, SinoMed, Chinese National Knowledge Infrastructure from their inception date to September 12, 2017 for comparative studies on IBS and IBD patients. Standardized mean differences (SMDs) and odds ratios (OR) of comorbid depression were calculated using random effect models. Data on comorbid anxiety in the included studies were also extracted and analyzed. Results: Altogether, 22 studies with 1,244 IBS and 1,048 IBD patients were included. While there was no significant group difference in the prevalence of depression (10 studies, OR = 1.18, 95%CI: 0.87–1.60, P = 0.29), the IBS group had more severe depression (pooled SMD = 0.18, 95%CI: 0.04–0.33, P = 0.01) and anxiety than the IBD group (pooled SMD = 0.31, 95%CI: 0.14–0.49, P = 0.0006). Sixteen (72.7%) studies were assessed as ‘high quality’ using the Newcastle–Ottawa Scale (NOS). Conclusions: Although the prevalence of comorbid depression was similar between groups, IBS patients had more severe comorbid depressive and anxiety symptoms compared to IBD patients. Appropriate assessment and treatment of depressive and anxiety symptoms in these patient groups should be implemented.

AB - Background: The prevalence of comorbid depression is high in chronic gastrointestinal disorders, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). For these two disorders in particular, the findings have not been consistent. This meta-analysis systematically compares the rates and severity of comorbid depression between IBS and IBD patients. Methods: A systematic literature search was conducted using PubMed, PsycINFO, Embase, Cochrane Library, Wan Fang, SinoMed, Chinese National Knowledge Infrastructure from their inception date to September 12, 2017 for comparative studies on IBS and IBD patients. Standardized mean differences (SMDs) and odds ratios (OR) of comorbid depression were calculated using random effect models. Data on comorbid anxiety in the included studies were also extracted and analyzed. Results: Altogether, 22 studies with 1,244 IBS and 1,048 IBD patients were included. While there was no significant group difference in the prevalence of depression (10 studies, OR = 1.18, 95%CI: 0.87–1.60, P = 0.29), the IBS group had more severe depression (pooled SMD = 0.18, 95%CI: 0.04–0.33, P = 0.01) and anxiety than the IBD group (pooled SMD = 0.31, 95%CI: 0.14–0.49, P = 0.0006). Sixteen (72.7%) studies were assessed as ‘high quality’ using the Newcastle–Ottawa Scale (NOS). Conclusions: Although the prevalence of comorbid depression was similar between groups, IBS patients had more severe comorbid depressive and anxiety symptoms compared to IBD patients. Appropriate assessment and treatment of depressive and anxiety symptoms in these patient groups should be implemented.

KW - Anxiety

KW - Depression

KW - Inflammatory bowel disease

KW - Irritable bowel syndrome

KW - Meta-analysis

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U2 - 10.1016/j.jad.2018.04.111

DO - 10.1016/j.jad.2018.04.111

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SP - 37

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JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

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