Comparison of BSA release behavior from electrospun PLGA and PLGA/Chitosan membranes

Li Li Wu, Xiao Ran Li, Hua Li, Xiao Yan Yuan

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


\In order to encpsulate and controlled-release bioactive proteins, three fibrous membranes, i.e., poly(L-lactide-co-glycolide)(PLGA), hybrid PLGA and chitosan(H-PLGA/CS), and core/shell PLGA/CS (C-PLGA/CS), were produced by emulsion electrospinning, co-electrospinning and coaxial electrospinning, respectively. Bovine serum albumin(BSA) was selected as a model protein. The loading efficiency of BSA in the PLGA membrane was 1.56%, lower than those of H-PLGA/CS(5.98%) and C-PLGA/CS(4.80%). BSA release profiles from the three membranes showed initial burst releases in the first 7 d and then sustained release for 28 d. Cumulative releases at the end of the releasing period, 28 d, from the above three membranes were nearly 63%, 88% and 94%, respectively, indicating that the introduction of chitosan and the core/shell fiber structure could enhance BSA release rate. In addition, all these electrospun membranes could retain their fibrous morphologies after in vitro release of BSA for 28 d.

Original languageEnglish
Pages (from-to)708-711
Number of pages4
JournalChemical Research in Chinese Universities
Issue number4
Publication statusPublished - 2011
Externally publishedYes


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