Abstract
Clostridium difficile is toxin-producing antimicrobial resistant (AMR) enteropathogen of international One Health importance. This thesis provides novel insights into the genetic diversity, evolutionary history, and zoonotic potential of C. difficile isolated from livestock and humans in Australia. Critically, this work has shown that livestock in Australia are reservoirs for clinically important, multi-drug resistant strains of C. difficile with a clear potential for interspecies transmission between animals and humans, findings which challenge the long-held misconception that C. difficile infection (CDI) is primarily a healthcare-associated infection.
Original language | English |
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Qualification | Doctor of Philosophy |
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Award date | 28 Feb 2018 |
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Publication status | Unpublished - 2018 |