Comparative phylogenomics and antimicrobial resistance in livestock-associated lineages of Clostridium difficile

Daniel Raymond Knight

Research output: ThesisDoctoral Thesis

Abstract

Clostridium difficile is toxin-producing antimicrobial resistant (AMR) enteropathogen of international One Health importance. This thesis provides novel insights into the genetic diversity, evolutionary history, and zoonotic potential of C. difficile isolated from livestock and humans in Australia. Critically, this work has shown that livestock in Australia are reservoirs for clinically important, multi-drug resistant strains of C. difficile with a clear potential for interspecies transmission between animals and humans, findings which challenge the long-held misconception that C. difficile infection (CDI) is primarily a healthcare-associated infection.
LanguageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Riley, Thomas, Supervisor
  • Chang, Barbara, Supervisor
  • Peacock, Christopher, Supervisor
Thesis sponsors
Award date28 Feb 2018
DOIs
StateUnpublished - 2018

Fingerprint

Clostridium difficile
Livestock
Zoonoses
Cross Infection
History
Infection
Pharmaceutical Preparations

Cite this

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title = "Comparative phylogenomics and antimicrobial resistance in livestock-associated lineages of Clostridium difficile",
abstract = "Clostridium difficile is toxin-producing antimicrobial resistant (AMR) enteropathogen of international One Health importance. This thesis provides novel insights into the genetic diversity, evolutionary history, and zoonotic potential of C. difficile isolated from livestock and humans in Australia. Critically, this work has shown that livestock in Australia are reservoirs for clinically important, multi-drug resistant strains of C. difficile with a clear potential for interspecies transmission between animals and humans, findings which challenge the long-held misconception that C. difficile infection (CDI) is primarily a healthcare-associated infection.",
keywords = "Clostridium difficile, Genomics, Bioinformatics, Molecular epidemiology, Animal health, One health, Antimicrobial resistance, Evolution",
author = "Knight, {Daniel Raymond}",
year = "2018",
doi = "10.4225/23/5aa61a38348ac",
language = "English",
school = "The University of Western Australia",

}

TY - THES

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PY - 2018

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AB - Clostridium difficile is toxin-producing antimicrobial resistant (AMR) enteropathogen of international One Health importance. This thesis provides novel insights into the genetic diversity, evolutionary history, and zoonotic potential of C. difficile isolated from livestock and humans in Australia. Critically, this work has shown that livestock in Australia are reservoirs for clinically important, multi-drug resistant strains of C. difficile with a clear potential for interspecies transmission between animals and humans, findings which challenge the long-held misconception that C. difficile infection (CDI) is primarily a healthcare-associated infection.

KW - Clostridium difficile

KW - Genomics

KW - Bioinformatics

KW - Molecular epidemiology

KW - Animal health

KW - One health

KW - Antimicrobial resistance

KW - Evolution

U2 - 10.4225/23/5aa61a38348ac

DO - 10.4225/23/5aa61a38348ac

M3 - Doctoral Thesis

ER -