Comparative phylogenomics and antimicrobial resistance in livestock-associated lineages of Clostridium difficile

Daniel Raymond Knight

doi:10.4225/23/5aa61a38348ac

Comparative phylogenomics and antimicrobial resistance in livestock-associated lineages of Clostridium difficile

Daniel Raymond Knight

School of Biomedical Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Clostridium difficile is toxin-producing antimicrobial resistant (AMR) enteropathogen of international One Health importance. This thesis provides novel insights into the genetic diversity, evolutionary history, and zoonotic potential of C. difficile isolated from livestock and humans in Australia. Critically, this work has shown that livestock in Australia are reservoirs for clinically important, multi-drug resistant strains of C. difficile with a clear potential for interspecies transmission between animals and humans, findings which challenge the long-held misconception that C. difficile infection (CDI) is primarily a healthcare-associated infection.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Riley, Thomas, Supervisor Chang, Barbara, Supervisor Peacock, Christopher, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	28 Feb 2018
DOIs	https://doi.org/10.4225/23/5aa61a38348ac
Publication status	Unpublished - 2018

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10.4225/23/5aa61a38348ac

THESIS - DOCTOR OF PHILOSOPHY - KNIGHT Daniel Raymond - 2018
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Cite this

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title = "Comparative phylogenomics and antimicrobial resistance in livestock-associated lineages of Clostridium difficile",

abstract = "Clostridium difficile is toxin-producing antimicrobial resistant (AMR) enteropathogen of international One Health importance. This thesis provides novel insights into the genetic diversity, evolutionary history, and zoonotic potential of C. difficile isolated from livestock and humans in Australia. Critically, this work has shown that livestock in Australia are reservoirs for clinically important, multi-drug resistant strains of C. difficile with a clear potential for interspecies transmission between animals and humans, findings which challenge the long-held misconception that C. difficile infection (CDI) is primarily a healthcare-associated infection.",

keywords = "Clostridium difficile, Genomics, Bioinformatics, Molecular epidemiology, Animal health, One health, Antimicrobial resistance, Evolution",

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AB - Clostridium difficile is toxin-producing antimicrobial resistant (AMR) enteropathogen of international One Health importance. This thesis provides novel insights into the genetic diversity, evolutionary history, and zoonotic potential of C. difficile isolated from livestock and humans in Australia. Critically, this work has shown that livestock in Australia are reservoirs for clinically important, multi-drug resistant strains of C. difficile with a clear potential for interspecies transmission between animals and humans, findings which challenge the long-held misconception that C. difficile infection (CDI) is primarily a healthcare-associated infection.

KW - Clostridium difficile

KW - Genomics

KW - Bioinformatics

KW - Molecular epidemiology

KW - Animal health

KW - One health

KW - Antimicrobial resistance

KW - Evolution

U2 - 10.4225/23/5aa61a38348ac

DO - 10.4225/23/5aa61a38348ac

M3 - Doctoral Thesis

ER -

Comparative phylogenomics and antimicrobial resistance in livestock-associated lineages of Clostridium difficile

Abstract

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