TY - JOUR
T1 - Comparative genomics: From genotype to disease phenotype in the leishmaniases
AU - Smith, D.F.
AU - Peacock, Christopher
AU - Cruz, A.K.
PY - 2007
Y1 - 2007
N2 - Recent progress in sequencing the genomes of several Leishmania species, causative agents of cutaneous, mucocutaneous and visceral leishmaniasis, is revealing unusual features of potential relevance to parasite virulence and pathogenesis in the host. While the genomes of Leishmania major, Leishmania braziliensis and Leishmania infantum are highly similar in content and organisation, species-specific genes and mechanisms distinguish one from another. In particular, the presence of retrotransposons and the components of a putative RNA interference machinery in L. braziliensis suggest the potential for both greater diversity and more tractable experimentation in this Leishmania Viannia species. (c) 2007 Australian society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
AB - Recent progress in sequencing the genomes of several Leishmania species, causative agents of cutaneous, mucocutaneous and visceral leishmaniasis, is revealing unusual features of potential relevance to parasite virulence and pathogenesis in the host. While the genomes of Leishmania major, Leishmania braziliensis and Leishmania infantum are highly similar in content and organisation, species-specific genes and mechanisms distinguish one from another. In particular, the presence of retrotransposons and the components of a putative RNA interference machinery in L. braziliensis suggest the potential for both greater diversity and more tractable experimentation in this Leishmania Viannia species. (c) 2007 Australian society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.ijpara.2007.05.015
DO - 10.1016/j.ijpara.2007.05.015
M3 - Literature review
C2 - 17645880
VL - 37
SP - 1173
EP - 1186
JO - International Journal of Parasitology
JF - International Journal of Parasitology
SN - 0020-7519
ER -