Comparative genomic analysis of three Leishmania species that cause diverse human disease

Christopher Peacock; K. Seeger; D. Harris; L. Murphy; J.C. Ruiz; M.A. Quail; N. Peters; E. Adlem; A. Tivey; M. Aslett; A. Kerhornou; A. Ivens; A. Fraser; M.A. Rajandream; T. Carver; H. Norbertczak; T. Chillingworth; Z. Hance; K. Jagels; S. Moule; D. Ormond; S. Rutter; R. Squares; S. Whitehead; E. Rabbinowitsch; C. Arrowsmith; B. White; S. Thurston; F. Bringaud; S.L. Baldauf; A. Faulconbridge; D. Jeffares; D.P. Depledge; S.O. Oyola; J.D. Hilley; L.O. Brito; L.R.O. Tosi; B. Barrell; A.K. Cruz; J.C. Mottram; D.F. Smith; M. Berriman

doi:10.1038/ng2053

Comparative genomic analysis of three Leishmania species that cause diverse human disease

Christopher Peacock
, K. Seeger
, D. Harris
, L. Murphy
, J.C. Ruiz
, M.A. Quail
, N. Peters
, E. Adlem
, A. Tivey
, M. Aslett
, A. Kerhornou
, A. Ivens
, A. Fraser
, M.A. Rajandream
, T. Carver
, H. Norbertczak
, T. Chillingworth
, Z. Hance
, K. Jagels
, S. Moule

D. Ormond, S. Rutter, R. Squares, S. Whitehead, E. Rabbinowitsch, C. Arrowsmith, B. White, S. Thurston, F. Bringaud, S.L. Baldauf, A. Faulconbridge, D. Jeffares, D.P. Depledge, S.O. Oyola, J.D. Hilley, L.O. Brito, L.R.O. Tosi, B. Barrell, A.K. Cruz, J.C. Mottram, D.F. Smith, M. Berriman

Marshall Centre

Research output: Contribution to journal › Article › peer-review

661 Citations (Scopus)

Abstract

Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only similar to 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA- mediated interference pathway, telomere- associated transposable elements and spliced leader - associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host- pathogen interactions and parasite survival in the macrophage.

Original language	English
Pages (from-to)	839-847
Journal	Nature Genetics
Volume	39
DOIs	https://doi.org/10.1038/ng2053
Publication status	Published - 2007

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Peacock, C., Seeger, K., Harris, D., Murphy, L., Ruiz, J. C., Quail, M. A., Peters, N., Adlem, E., Tivey, A., Aslett, M., Kerhornou, A., Ivens, A., Fraser, A., Rajandream, M. A., Carver, T., Norbertczak, H., Chillingworth, T., Hance, Z., Jagels, K., ... Berriman, M. (2007). Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nature Genetics, 39, 839-847. https://doi.org/10.1038/ng2053

@article{b09db8bc59654408a43f1c06fc3b2276,

title = "Comparative genomic analysis of three Leishmania species that cause diverse human disease",

abstract = "Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only similar to 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA- mediated interference pathway, telomere- associated transposable elements and spliced leader - associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host- pathogen interactions and parasite survival in the macrophage.",

author = "Christopher Peacock and K. Seeger and D. Harris and L. Murphy and J.C. Ruiz and M.A. Quail and N. Peters and E. Adlem and A. Tivey and M. Aslett and A. Kerhornou and A. Ivens and A. Fraser and M.A. Rajandream and T. Carver and H. Norbertczak and T. Chillingworth and Z. Hance and K. Jagels and S. Moule and D. Ormond and S. Rutter and R. Squares and S. Whitehead and E. Rabbinowitsch and C. Arrowsmith and B. White and S. Thurston and F. Bringaud and S.L. Baldauf and A. Faulconbridge and D. Jeffares and D.P. Depledge and S.O. Oyola and J.D. Hilley and L.O. Brito and L.R.O. Tosi and B. Barrell and A.K. Cruz and J.C. Mottram and D.F. Smith and M. Berriman",

year = "2007",

doi = "10.1038/ng2053",

language = "English",

volume = "39",

pages = "839--847",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

}

Peacock, C, Seeger, K, Harris, D, Murphy, L, Ruiz, JC, Quail, MA, Peters, N, Adlem, E, Tivey, A, Aslett, M, Kerhornou, A, Ivens, A, Fraser, A, Rajandream, MA, Carver, T, Norbertczak, H, Chillingworth, T, Hance, Z, Jagels, K, Moule, S, Ormond, D, Rutter, S, Squares, R, Whitehead, S, Rabbinowitsch, E, Arrowsmith, C, White, B, Thurston, S, Bringaud, F, Baldauf, SL, Faulconbridge, A, Jeffares, D, Depledge, DP, Oyola, SO, Hilley, JD, Brito, LO, Tosi, LRO, Barrell, B, Cruz, AK, Mottram, JC, Smith, DF & Berriman, M 2007, 'Comparative genomic analysis of three Leishmania species that cause diverse human disease', Nature Genetics, vol. 39, pp. 839-847. https://doi.org/10.1038/ng2053

TY - JOUR

T1 - Comparative genomic analysis of three Leishmania species that cause diverse human disease

AU - Peacock, Christopher

AU - Seeger, K.

AU - Harris, D.

AU - Murphy, L.

AU - Ruiz, J.C.

AU - Quail, M.A.

AU - Peters, N.

AU - Adlem, E.

AU - Tivey, A.

AU - Aslett, M.

AU - Kerhornou, A.

AU - Ivens, A.

AU - Fraser, A.

AU - Rajandream, M.A.

AU - Carver, T.

AU - Norbertczak, H.

AU - Chillingworth, T.

AU - Hance, Z.

AU - Jagels, K.

AU - Moule, S.

AU - Ormond, D.

AU - Rutter, S.

AU - Squares, R.

AU - Whitehead, S.

AU - Rabbinowitsch, E.

AU - Arrowsmith, C.

AU - White, B.

AU - Thurston, S.

AU - Bringaud, F.

AU - Baldauf, S.L.

AU - Faulconbridge, A.

AU - Jeffares, D.

AU - Depledge, D.P.

AU - Oyola, S.O.

AU - Hilley, J.D.

AU - Brito, L.O.

AU - Tosi, L.R.O.

AU - Barrell, B.

AU - Cruz, A.K.

AU - Mottram, J.C.

AU - Smith, D.F.

AU - Berriman, M.

PY - 2007

Y1 - 2007

N2 - Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only similar to 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA- mediated interference pathway, telomere- associated transposable elements and spliced leader - associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host- pathogen interactions and parasite survival in the macrophage.

AB - Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only similar to 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA- mediated interference pathway, telomere- associated transposable elements and spliced leader - associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host- pathogen interactions and parasite survival in the macrophage.

U2 - 10.1038/ng2053

DO - 10.1038/ng2053

M3 - Article

C2 - 17572675

SN - 1061-4036

VL - 39

SP - 839

EP - 847

JO - Nature Genetics

JF - Nature Genetics

ER -

Comparative genomic analysis of three Leishmania species that cause diverse human disease

Abstract

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