Comparative analysis of human and marsupial Leishmania: Characterisation of Leishmania australiensis, development of a potential human attenuated vaccine and assessment of vector competence

Calila Sena Santos

Research output: ThesisDoctoral Thesis

231 Downloads (Pure)

Abstract

Leishmania parasites are protozoans able to infect many vertebrates including humans. Leishmania macropodum causes leishmaniasis in Australian marsupials. This study examined Leishmania macropodum in vitro life cycle, resistance to complement mediate lysis and in vivo responses to infection in the mouse model. It utilised an experimental murine infection system to examine the possible use of Leishmania macropodum as a safe, attenuated vaccine against human leishmaniasis. Furthermore, using in silico analysis, the main receptors used in parasite-vector interaction were analysed. Leishmania macropodum is resistant to normal mouse serum and can cause transient infection in mice. These and other results are discussed.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date5 Jul 2018
DOIs
Publication statusUnpublished - 2018

    Fingerprint

Cite this