Common HLA-B8-DR3 haplotype in Northern India is different from that found in Europe

C.S. Witt, Patricia Price, G. Kaur, Karey Cheong, U. Kanga, Frank Christiansen, D. Sayer, N.K. Mehra

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    The aim of this study was to determine whether a common diabetic haplotype, including human leukocyte antigen (HLA)-B8 and HLA-DR3, in Northern India is the same haplotype as the European HLA-B8-DR3 haplotype. DNA samples from Northern Indian subjects selected on the basis of HLA-B8 and BLA-DR3 were tested for microsatellite and single nucleotide polymorphism alleles throughout the major histocompatibility complex (MHC). It was found that the Indian samples represent a conserved haplotype in which all alleles were shared by Indian subjects with HLA-B8 and HLA-DR3, but were different to those that are characteristic of the European 8.1 ancestral haplotype. The Indian and European haplotypes share]HLA-B*0801, HLA-DRB1*0301 and HLA-DQB1*02 but differ for subtypes of BLA-Cw*07 and BLA-DRB3 and all central MHC alleles tested. In contrast, Indian subjects selected on the basis of HLA-B58 ( 1-17) and BLA-DR3 shared the same alleles at other MHC loci as have been described in the common Chinese haplotype with HLA-B58/17 and HLA-DR3. A third haplotype, HLA-B50/21 and HLA-DR3, was also found to be highly conserved but shares little in common with the other two BLA-DR3-containing Indian haplotypes.
    Original languageEnglish
    Pages (from-to)474-480
    JournalTissue Antigens
    Publication statusPublished - 2002


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