Commissioning and performance characteristics of a pre‑clinical image‑guided radiotherapy system

Theresa Feddersen, Pejman Rowshan Farzad, Tamara Abel, Martin Ebert

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Characteristics of a small-animal radiotherapy device, the X-RAD SmART, are described following commissioning of the device for pre-clinical radiotherapy research. Performance characteristics were assessed using published standards and compared with previous results published for similar systems. Operational radiation safety was established. Device X-ray beam quality and output dose-rate were found to be consistent with those reported for similar devices. Output steadily declined over 18 months though remained within tolerance levels. There is considerable variation in output factor across the international installations for the smallest field size (varying by more than 30% for 2.5 mm diameter fields). Measured depth dose and profile data was mostly consistent with that published, with some differences in penumbrae and generally reduced flatness. Target localisation is achieved with an imaging panel and with automatic corrections for panel flex and device mechanical instability, targeting within 0.2 mm is achievable. The small-animal image-guided radiotherapy platform has been implemented and assessed and found to perform as specified. The combination of kV energy and high spatial precision make it suitable for replicating clinical dose distributions at the small-animal scale, though dosimetric uncertainties for the narrowest fields need to be acknowledged.
Original languageEnglish
Pages (from-to)541-551
Number of pages11
JournalAustralasian Physical & Engineering Sciences In Medicine
Issue number2
Early online date15 Apr 2019
Publication statusPublished - 15 Jun 2019


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