TY - GEN
T1 - Combined THz and OCT characterization of biologically relevant tissue phantoms
AU - Fitzgerald, Anthony J.
AU - Jayasree, Stephy V.K.
AU - Cense, Barry
AU - Wallace, Vincent P.
PY - 2020/11/8
Y1 - 2020/11/8
N2 - Terahertz (THz) imaging and optical coherence tomography (OCT) provide similar information over the same scales. Here, we present an iterative algorithm that combines the information from OCT and THz within an object to determine both the depth of the reflecting layers at different locations. Also, we can extract unknown refractive index of the object for both the OCT wavelengths and THz frequencies. We validate this algorithm using a phantom test object with embedded layers and show that the depths and refractive index values obtained from the algorithm agreed with the measured values to within 3%. We further demonstrate for the first time that OCT and THz images can be co-registered and aligned using unsupervised image registration. Hence, we show that a combined OCT/THz system can provide unique information beyond the capability of the separate modalities alone, with possible applications in the medical and industrial sectors.
AB - Terahertz (THz) imaging and optical coherence tomography (OCT) provide similar information over the same scales. Here, we present an iterative algorithm that combines the information from OCT and THz within an object to determine both the depth of the reflecting layers at different locations. Also, we can extract unknown refractive index of the object for both the OCT wavelengths and THz frequencies. We validate this algorithm using a phantom test object with embedded layers and show that the depths and refractive index values obtained from the algorithm agreed with the measured values to within 3%. We further demonstrate for the first time that OCT and THz images can be co-registered and aligned using unsupervised image registration. Hence, we show that a combined OCT/THz system can provide unique information beyond the capability of the separate modalities alone, with possible applications in the medical and industrial sectors.
UR - http://www.scopus.com/inward/record.url?scp=85103149427&partnerID=8YFLogxK
U2 - 10.1109/IRMMW-THz46771.2020.9370767
DO - 10.1109/IRMMW-THz46771.2020.9370767
M3 - Conference paper
AN - SCOPUS:85103149427
T3 - International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
BT - 2020 45th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2020
PB - IEEE, Institute of Electrical and Electronics Engineers
CY - USA
T2 - 45th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2020
Y2 - 8 November 2020 through 13 November 2020
ER -