Combinatorial ion channel inhibitor therapy for the treatment of CNS injury: a therapeutic optimisation approach

Ryan Louis O'Hare Doig

doi:10.4225/23/5a1667858fb21

Combinatorial ion channel inhibitor therapy for the treatment of CNS injury: a therapeutic optimisation approach

Ryan Louis O'Hare Doig

School of Biological Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Spinal cord injury {SCI) is a devastating event that can result in paralysis or even death. Following SCI, cells beyond the primar injury site undergo secondary degeneration, contributing to chronic deterioration of morphological and functional outcomes. A variety of models were used to: (1) define oxidative events during early time phases of secondary degeneration; (2) define effects of various combinations of ion channel inhibitors using in vitro and in vivo models of neurotrauma and (3) assess the efficacy of the optimal combination of ionchannel inhibitors in a clinically relevant contusion model of thoracic SCI.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Hodgetts, Stuart, Supervisor Fitzgerald, Melinda, Supervisor
Award date	15 Nov 2017
DOIs	https://doi.org/10.4225/23/5a1667858fb21
Publication status	Unpublished - 2017

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10.4225/23/5a1667858fb21

THESIS - DOCTOR OF PHILOSOPHY - DOIG Ryan Loius O Hare - 2017
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Cite this

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title = "Combinatorial ion channel inhibitor therapy for the treatment of CNS injury: a therapeutic optimisation approach",

abstract = "Spinal cord injury {SCI) is a devastating event that can result in paralysis or even death. Following SCI, cells beyond the primar injury site undergo secondary degeneration, contributing to chronic deterioration of morphological and functional outcomes. A variety of models were used to: (1) define oxidative events during early time phases of secondary degeneration; (2) define effects of various combinations of ion channel inhibitors using in vitro and in vivo models of neurotrauma and (3) assess the efficacy of the optimal combination of ionchannel inhibitors in a clinically relevant contusion model of thoracic SCI.",

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AB - Spinal cord injury {SCI) is a devastating event that can result in paralysis or even death. Following SCI, cells beyond the primar injury site undergo secondary degeneration, contributing to chronic deterioration of morphological and functional outcomes. A variety of models were used to: (1) define oxidative events during early time phases of secondary degeneration; (2) define effects of various combinations of ion channel inhibitors using in vitro and in vivo models of neurotrauma and (3) assess the efficacy of the optimal combination of ionchannel inhibitors in a clinically relevant contusion model of thoracic SCI.

KW - Spinal cord injury

KW - Neurotrauma

KW - Oxidative stress

KW - Myelin

KW - Secondary degeneration

KW - Ion channel inhibitor

U2 - 10.4225/23/5a1667858fb21

DO - 10.4225/23/5a1667858fb21

M3 - Doctoral Thesis

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Combinatorial ion channel inhibitor therapy for the treatment of CNS injury: a therapeutic optimisation approach

Abstract

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