Combinatorial ion channel inhibitor therapy for the treatment of CNS injury: a therapeutic optimisation approach

Ryan Louis O'Hare Doig

Research output: ThesisDoctoral Thesis

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Abstract

Spinal cord injury {SCI) is a devastating event that can result in paralysis or even death. Following SCI, cells beyond the primar injury site undergo secondary degeneration, contributing to chronic deterioration of morphological and functional outcomes. A variety of models were used to: (1) define oxidative events during early time phases of secondary degeneration; (2) define effects of various combinations of ion channel inhibitors using in vitro and in vivo models of neurotrauma and (3) assess the efficacy of the optimal combination of ionchannel inhibitors in a clinically relevant contusion model of thoracic SCI.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date15 Nov 2017
DOIs
Publication statusUnpublished - 2017

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