Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting

Ruhani Singh; Diwei Ho; Lee-Yong Lim; K. Swaminatha Iyer; Nicole M. Smith

doi:10.1021/acsomega.6b00239

Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting

Ruhani Singh, Diwei Ho, Lee-Yong Lim, K. Swaminatha Iyer, Nicole M. Smith

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Colloidal poly(glycidyl methacrylate) nanoparticles (NPs) are demonstrated to be platforms facilitating the “click” chemistry approach of surface functionalization for receptor targeting. Folate receptor-targeted NPs were synthesized, physicochemically characterized, confirmed for their biocompatibility, and validated for their selective targeting capabilities for ovarian cancer cells in vitro.

Original language	English
Pages (from-to)	1114-1120
Number of pages	7
Journal	ACS Omega
Volume	1
Issue number	6
DOIs	https://doi.org/10.1021/acsomega.6b00239
Publication status	Published - 6 Dec 2016

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title = "Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting",

abstract = "Colloidal poly(glycidyl methacrylate) nanoparticles (NPs) are demonstrated to be platforms facilitating the “click” chemistry approach of surface functionalization for receptor targeting. Folate receptor-targeted NPs were synthesized, physicochemically characterized, confirmed for their biocompatibility, and validated for their selective targeting capabilities for ovarian cancer cells in vitro.",

author = "Ruhani Singh and Diwei Ho and Lee-Yong Lim and {Swaminatha Iyer}, K. and Smith, {Nicole M.}",

year = "2016",

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doi = "10.1021/acsomega.6b00239",

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AU - Singh, Ruhani

AU - Ho, Diwei

AU - Lim, Lee-Yong

AU - Swaminatha Iyer, K.

AU - Smith, Nicole M.

PY - 2016/12/6

Y1 - 2016/12/6

N2 - Colloidal poly(glycidyl methacrylate) nanoparticles (NPs) are demonstrated to be platforms facilitating the “click” chemistry approach of surface functionalization for receptor targeting. Folate receptor-targeted NPs were synthesized, physicochemically characterized, confirmed for their biocompatibility, and validated for their selective targeting capabilities for ovarian cancer cells in vitro.

AB - Colloidal poly(glycidyl methacrylate) nanoparticles (NPs) are demonstrated to be platforms facilitating the “click” chemistry approach of surface functionalization for receptor targeting. Folate receptor-targeted NPs were synthesized, physicochemically characterized, confirmed for their biocompatibility, and validated for their selective targeting capabilities for ovarian cancer cells in vitro.

U2 - 10.1021/acsomega.6b00239

DO - 10.1021/acsomega.6b00239

M3 - Article

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EP - 1120

JO - ACS Omega

JF - ACS Omega

IS - 6

ER -

Colloidal Polymeric Platform for Facile Click-Assisted Ligand Functionalization and Receptor Targeting

Abstract

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