Collagen and Muscle Fibrous Tissue as a Contrast Mechanism in the THz region

Shuting Fan, Zhengfang Qian, Vincent P. Wallace

Research output: Chapter in Book/Conference paperConference paper

Abstract

We imaged a thin paraffin embedded sample with a terahertz time domain spectroscopy (THz-TDS) system. The sample was prepared from the laboratory Guinea pigs after 7 weeks recovery from a brain surgery. The surgical wound and the surrounding normal skin tissue showed a clear contrast in the terahertz band despite of the sub-wavelength thickness of the sample. The comparison between the terahertz images and the stained histological images suggests that the contrast comes from the collagen-rich wound and the muscle fibrous tissue. This work demonstrates a potential contrast mechanism in terahertz tissue imaging.

Original languageEnglish
Title of host publication2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018
PublisherIEEE, Institute of Electrical and Electronics Engineers
Volume2018-September
ISBN (Electronic)9781538638095
DOIs
Publication statusPublished - 25 Oct 2018
Event43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018 - Nagoya, Japan
Duration: 9 Sep 201814 Sep 2018

Conference

Conference43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018
CountryJapan
CityNagoya
Period9/09/1814/09/18

Fingerprint

Collagen
Muscle
Tissue
Paraffins
Surgery
Brain
Skin
Spectroscopy
Imaging techniques
Recovery
Wavelength

Cite this

Fan, S., Qian, Z., & Wallace, V. P. (2018). Collagen and Muscle Fibrous Tissue as a Contrast Mechanism in the THz region. In 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018 (Vol. 2018-September). [8509855] IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/IRMMW-THz.2018.8509855
Fan, Shuting ; Qian, Zhengfang ; Wallace, Vincent P. / Collagen and Muscle Fibrous Tissue as a Contrast Mechanism in the THz region. 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. Vol. 2018-September IEEE, Institute of Electrical and Electronics Engineers, 2018.
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Fan, S, Qian, Z & Wallace, VP 2018, Collagen and Muscle Fibrous Tissue as a Contrast Mechanism in the THz region. in 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. vol. 2018-September, 8509855, IEEE, Institute of Electrical and Electronics Engineers, 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018, Nagoya, Japan, 9/09/18. https://doi.org/10.1109/IRMMW-THz.2018.8509855

Collagen and Muscle Fibrous Tissue as a Contrast Mechanism in the THz region. / Fan, Shuting; Qian, Zhengfang; Wallace, Vincent P.

2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. Vol. 2018-September IEEE, Institute of Electrical and Electronics Engineers, 2018. 8509855.

Research output: Chapter in Book/Conference paperConference paper

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AB - We imaged a thin paraffin embedded sample with a terahertz time domain spectroscopy (THz-TDS) system. The sample was prepared from the laboratory Guinea pigs after 7 weeks recovery from a brain surgery. The surgical wound and the surrounding normal skin tissue showed a clear contrast in the terahertz band despite of the sub-wavelength thickness of the sample. The comparison between the terahertz images and the stained histological images suggests that the contrast comes from the collagen-rich wound and the muscle fibrous tissue. This work demonstrates a potential contrast mechanism in terahertz tissue imaging.

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Fan S, Qian Z, Wallace VP. Collagen and Muscle Fibrous Tissue as a Contrast Mechanism in the THz region. In 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. Vol. 2018-September. IEEE, Institute of Electrical and Electronics Engineers. 2018. 8509855 https://doi.org/10.1109/IRMMW-THz.2018.8509855