Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation

J. Danesh; A. Hingorani; F. Wensley; J.P. Casas; L. Smeeth; N.J. Samani; P. Whincup; R. Morris; D.A. Lawlor; G.D. Smith; N. Timpson; S. Ebrahim; M. Brown; M. Sandhu; A. Reiner; B. Psaty; L. Lange; M. Cushman; R. Tracy; B.G. Nordestgaard; A. Tybjaerg-Hansen; J. Zacho; J. Hung; P. Thompson; John Beilby; Lyle Palmer; G. Fowkes; G. Lowe; I. Tzoulaki; M. Kumari; K. Overvad; K.T. Khaw; E. Benjamin; B. Chiodini; M. Franzosi; Paul Norman; G.J. Hankey; K. Jamrozik; E. Rimm; J. Pai; S. Heckbert; J. Bis; S. Yusuf; S. Anand; J. Engort; R. Collins; O. Melander; G. Berglund; P. Ladenvall; L. Johansson; J.H. Jansson; G. Hallmans; S. Humphries; J. Manson; D. Saleheen; P. Frossard; N. Sattar; M. Robertson; J. Shepherd; E. Schaefer; A. Hofman; J.C. Witteman; I. Kardys; U. De Faire; A. Bennet; D. O'Reilly; A. Mcmahon; C. Packard; R. Clarke; P. Greenland; J. Bowden; E. Di Angelantonio; T. Shah; S. Thompson; C. Verzilli; M. Walker; J. Whittaker

doi:10.1007/s10654-008-9249-z

Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation

J. Danesh, A. Hingorani, F. Wensley, J.P. Casas, L. Smeeth, N.J. Samani, P. Whincup, R. Morris, D.A. Lawlor, G.D. Smith, N. Timpson, S. Ebrahim, M. Brown, M. Sandhu, A. Reiner, B. Psaty, L. Lange, M. Cushman, R. Tracy, B.G. NordestgaardA. Tybjaerg-Hansen, J. Zacho, J. Hung, P. Thompson, John Beilby, Lyle Palmer, G. Fowkes, G. Lowe, I. Tzoulaki, M. Kumari, K. Overvad, K.T. Khaw, E. Benjamin, B. Chiodini, M. Franzosi, Paul Norman, G.J. Hankey, K. Jamrozik, E. Rimm, J. Pai, S. Heckbert, J. Bis, S. Yusuf, S. Anand, J. Engort, R. Collins, O. Melander, G. Berglund, P. Ladenvall, L. Johansson, J.H. Jansson, G. Hallmans, S. Humphries, J. Manson, D. Saleheen, P. Frossard, N. Sattar, M. Robertson, J. Shepherd, E. Schaefer, A. Hofman, J.C. Witteman, I. Kardys, U. De Faire, A. Bennet, D. O'Reilly, A. Mcmahon, C. Packard, R. Clarke, P. Greenland, J. Bowden, E. Di Angelantonio, T. Shah, S. Thompson, C. Verzilli, M. Walker, J. Whittaker

Research output: Contribution to journal › Article

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Abstract

Many prospective studies have reported associations between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD), but causality remains uncertain. Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associated with circulating concentrations, thereby utilising these variants as proxies for circulating CRP levels. By analysing data from several studies examining the association between relevant CRP polymorphisms and CHD risk, the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk. A central database is being established containing individual data on CRP polymorphisms, circulating CRP levels, and major coronary outcomes as well as age, sex and other relevant characteristics. Associations between CRP polymorphisms or haplotypes and CHD will be evaluated under different circumstances. This collaboration comprises, at present, about 37,000 CHD outcomes and about 120,000 controls, which should yield suitably precise findings to help judge causality. This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis.

Original language	English
Pages (from-to)	531-540
Journal	European Journal of Epidemiology
Volume	23
Issue number	8
DOIs	https://doi.org/10.1007/s10654-008-9249-z
Publication status	Published - 2008

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Danesh, J., Hingorani, A., Wensley, F., Casas, J. P., Smeeth, L., Samani, N. J., Whincup, P., Morris, R., Lawlor, D. A., Smith, G. D., Timpson, N., Ebrahim, S., Brown, M., Sandhu, M., Reiner, A., Psaty, B., Lange, L., Cushman, M., Tracy, R., ... Whittaker, J. (2008). Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation. European Journal of Epidemiology, 23(8), 531-540. https://doi.org/10.1007/s10654-008-9249-z

Danesh, J. ; Hingorani, A. ; Wensley, F. ; Casas, J.P. ; Smeeth, L. ; Samani, N.J. ; Whincup, P. ; Morris, R. ; Lawlor, D.A. ; Smith, G.D. ; Timpson, N. ; Ebrahim, S. ; Brown, M. ; Sandhu, M. ; Reiner, A. ; Psaty, B. ; Lange, L. ; Cushman, M. ; Tracy, R. ; Nordestgaard, B.G. ; Tybjaerg-Hansen, A. ; Zacho, J. ; Hung, J. ; Thompson, P. ; Beilby, John ; Palmer, Lyle ; Fowkes, G. ; Lowe, G. ; Tzoulaki, I. ; Kumari, M. ; Overvad, K. ; Khaw, K.T. ; Benjamin, E. ; Chiodini, B. ; Franzosi, M. ; Norman, Paul ; Hankey, G.J. ; Jamrozik, K. ; Rimm, E. ; Pai, J. ; Heckbert, S. ; Bis, J. ; Yusuf, S. ; Anand, S. ; Engort, J. ; Collins, R. ; Melander, O. ; Berglund, G. ; Ladenvall, P. ; Johansson, L. ; Jansson, J.H. ; Hallmans, G. ; Humphries, S. ; Manson, J. ; Saleheen, D. ; Frossard, P. ; Sattar, N. ; Robertson, M. ; Shepherd, J. ; Schaefer, E. ; Hofman, A. ; Witteman, J.C. ; Kardys, I. ; De Faire, U. ; Bennet, A. ; O'Reilly, D. ; Mcmahon, A. ; Packard, C. ; Clarke, R. ; Greenland, P. ; Bowden, J. ; Di Angelantonio, E. ; Shah, T. ; Thompson, S. ; Verzilli, C. ; Walker, M. ; Whittaker, J. / Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation. In: European Journal of Epidemiology. 2008 ; Vol. 23, No. 8. pp. 531-540.

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title = "Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation",

abstract = "Many prospective studies have reported associations between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD), but causality remains uncertain. Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associated with circulating concentrations, thereby utilising these variants as proxies for circulating CRP levels. By analysing data from several studies examining the association between relevant CRP polymorphisms and CHD risk, the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk. A central database is being established containing individual data on CRP polymorphisms, circulating CRP levels, and major coronary outcomes as well as age, sex and other relevant characteristics. Associations between CRP polymorphisms or haplotypes and CHD will be evaluated under different circumstances. This collaboration comprises, at present, about 37,000 CHD outcomes and about 120,000 controls, which should yield suitably precise findings to help judge causality. This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis.",

author = "J. Danesh and A. Hingorani and F. Wensley and J.P. Casas and L. Smeeth and N.J. Samani and P. Whincup and R. Morris and D.A. Lawlor and G.D. Smith and N. Timpson and S. Ebrahim and M. Brown and M. Sandhu and A. Reiner and B. Psaty and L. Lange and M. Cushman and R. Tracy and B.G. Nordestgaard and A. Tybjaerg-Hansen and J. Zacho and J. Hung and P. Thompson and John Beilby and Lyle Palmer and G. Fowkes and G. Lowe and I. Tzoulaki and M. Kumari and K. Overvad and K.T. Khaw and E. Benjamin and B. Chiodini and M. Franzosi and Paul Norman and G.J. Hankey and K. Jamrozik and E. Rimm and J. Pai and S. Heckbert and J. Bis and S. Yusuf and S. Anand and J. Engort and R. Collins and O. Melander and G. Berglund and P. Ladenvall and L. Johansson and J.H. Jansson and G. Hallmans and S. Humphries and J. Manson and D. Saleheen and P. Frossard and N. Sattar and M. Robertson and J. Shepherd and E. Schaefer and A. Hofman and J.C. Witteman and I. Kardys and {De Faire}, U. and A. Bennet and D. O'Reilly and A. Mcmahon and C. Packard and R. Clarke and P. Greenland and J. Bowden and {Di Angelantonio}, E. and T. Shah and S. Thompson and C. Verzilli and M. Walker and J. Whittaker",

year = "2008",

doi = "10.1007/s10654-008-9249-z",

language = "English",

volume = "23",

pages = "531--540",

journal = "European Journal of Epidemiology",

issn = "0393-2990",

publisher = "Springer",

number = "8",

}

Danesh, J, Hingorani, A, Wensley, F, Casas, JP, Smeeth, L, Samani, NJ, Whincup, P, Morris, R, Lawlor, DA, Smith, GD, Timpson, N, Ebrahim, S, Brown, M, Sandhu, M, Reiner, A, Psaty, B, Lange, L, Cushman, M, Tracy, R, Nordestgaard, BG, Tybjaerg-Hansen, A, Zacho, J, Hung, J, Thompson, P, Beilby, J, Palmer, L, Fowkes, G, Lowe, G, Tzoulaki, I, Kumari, M, Overvad, K, Khaw, KT, Benjamin, E, Chiodini, B, Franzosi, M, Norman, P , Hankey, GJ, Jamrozik, K, Rimm, E, Pai, J, Heckbert, S, Bis, J, Yusuf, S, Anand, S, Engort, J, Collins, R, Melander, O, Berglund, G, Ladenvall, P, Johansson, L, Jansson, JH, Hallmans, G, Humphries, S, Manson, J, Saleheen, D, Frossard, P, Sattar, N, Robertson, M, Shepherd, J, Schaefer, E, Hofman, A, Witteman, JC, Kardys, I, De Faire, U, Bennet, A, O'Reilly, D, Mcmahon, A, Packard, C, Clarke, R, Greenland, P, Bowden, J, Di Angelantonio, E, Shah, T, Thompson, S, Verzilli, C, Walker, M & Whittaker, J 2008, 'Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation', European Journal of Epidemiology, vol. 23, no. 8, pp. 531-540. https://doi.org/10.1007/s10654-008-9249-z

Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation. / Danesh, J.; Hingorani, A.; Wensley, F.; Casas, J.P.; Smeeth, L.; Samani, N.J.; Whincup, P.; Morris, R.; Lawlor, D.A.; Smith, G.D.; Timpson, N.; Ebrahim, S.; Brown, M.; Sandhu, M.; Reiner, A.; Psaty, B.; Lange, L.; Cushman, M.; Tracy, R.; Nordestgaard, B.G.; Tybjaerg-Hansen, A.; Zacho, J.; Hung, J.; Thompson, P.; Beilby, John; Palmer, Lyle; Fowkes, G.; Lowe, G.; Tzoulaki, I.; Kumari, M.; Overvad, K.; Khaw, K.T.; Benjamin, E.; Chiodini, B.; Franzosi, M.; Norman, Paul ; Hankey, G.J.; Jamrozik, K.; Rimm, E.; Pai, J.; Heckbert, S.; Bis, J.; Yusuf, S.; Anand, S.; Engort, J.; Collins, R.; Melander, O.; Berglund, G.; Ladenvall, P.; Johansson, L.; Jansson, J.H.; Hallmans, G.; Humphries, S.; Manson, J.; Saleheen, D.; Frossard, P.; Sattar, N.; Robertson, M.; Shepherd, J.; Schaefer, E.; Hofman, A.; Witteman, J.C.; Kardys, I.; De Faire, U.; Bennet, A.; O'Reilly, D.; Mcmahon, A.; Packard, C.; Clarke, R.; Greenland, P.; Bowden, J.; Di Angelantonio, E.; Shah, T.; Thompson, S.; Verzilli, C.; Walker, M.; Whittaker, J.

In: European Journal of Epidemiology, Vol. 23, No. 8, 2008, p. 531-540.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation

AU - Danesh, J.

AU - Hingorani, A.

AU - Wensley, F.

AU - Casas, J.P.

AU - Smeeth, L.

AU - Samani, N.J.

AU - Whincup, P.

AU - Morris, R.

AU - Lawlor, D.A.

AU - Smith, G.D.

AU - Timpson, N.

AU - Ebrahim, S.

AU - Brown, M.

AU - Sandhu, M.

AU - Reiner, A.

AU - Psaty, B.

AU - Lange, L.

AU - Cushman, M.

AU - Tracy, R.

AU - Nordestgaard, B.G.

AU - Tybjaerg-Hansen, A.

AU - Zacho, J.

AU - Hung, J.

AU - Thompson, P.

AU - Beilby, John

AU - Palmer, Lyle

AU - Fowkes, G.

AU - Lowe, G.

AU - Tzoulaki, I.

AU - Kumari, M.

AU - Overvad, K.

AU - Khaw, K.T.

AU - Benjamin, E.

AU - Chiodini, B.

AU - Franzosi, M.

AU - Norman, Paul

AU - Hankey, G.J.

AU - Jamrozik, K.

AU - Rimm, E.

AU - Pai, J.

AU - Heckbert, S.

AU - Bis, J.

AU - Yusuf, S.

AU - Anand, S.

AU - Engort, J.

AU - Collins, R.

AU - Melander, O.

AU - Berglund, G.

AU - Ladenvall, P.

AU - Johansson, L.

AU - Jansson, J.H.

AU - Hallmans, G.

AU - Humphries, S.

AU - Manson, J.

AU - Saleheen, D.

AU - Frossard, P.

AU - Sattar, N.

AU - Robertson, M.

AU - Shepherd, J.

AU - Schaefer, E.

AU - Hofman, A.

AU - Witteman, J.C.

AU - Kardys, I.

AU - De Faire, U.

AU - Bennet, A.

AU - O'Reilly, D.

AU - Mcmahon, A.

AU - Packard, C.

AU - Clarke, R.

AU - Greenland, P.

AU - Bowden, J.

AU - Di Angelantonio, E.

AU - Shah, T.

AU - Thompson, S.

AU - Verzilli, C.

AU - Walker, M.

AU - Whittaker, J.

PY - 2008

Y1 - 2008

N2 - Many prospective studies have reported associations between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD), but causality remains uncertain. Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associated with circulating concentrations, thereby utilising these variants as proxies for circulating CRP levels. By analysing data from several studies examining the association between relevant CRP polymorphisms and CHD risk, the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk. A central database is being established containing individual data on CRP polymorphisms, circulating CRP levels, and major coronary outcomes as well as age, sex and other relevant characteristics. Associations between CRP polymorphisms or haplotypes and CHD will be evaluated under different circumstances. This collaboration comprises, at present, about 37,000 CHD outcomes and about 120,000 controls, which should yield suitably precise findings to help judge causality. This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis.

AB - Many prospective studies have reported associations between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD), but causality remains uncertain. Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associated with circulating concentrations, thereby utilising these variants as proxies for circulating CRP levels. By analysing data from several studies examining the association between relevant CRP polymorphisms and CHD risk, the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk. A central database is being established containing individual data on CRP polymorphisms, circulating CRP levels, and major coronary outcomes as well as age, sex and other relevant characteristics. Associations between CRP polymorphisms or haplotypes and CHD will be evaluated under different circumstances. This collaboration comprises, at present, about 37,000 CHD outcomes and about 120,000 controls, which should yield suitably precise findings to help judge causality. This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis.

U2 - 10.1007/s10654-008-9249-z

DO - 10.1007/s10654-008-9249-z

M3 - Article

C2 - 18425592

VL - 23

SP - 531

EP - 540

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 8

ER -