"Cold-Sensitive" Mutants of the Lac Repressor

Andrew Barker, S. Oehler, B. Muller-Hill

Research output: Contribution to journalArticlepeer-review


Thirteen of more than 4,000 single-amino-acid-replacement mutants of the Lac repressor, generated by suppression of amber nonsense mutants, were characterized as having a cold-sensitive phenotype. However, when expressed as missense mutations, none of the replacements cause cold sensitivity, implicating the suppression mechanism as being responsible for this phenotype.
Original languageEnglish
Pages (from-to)2174-2175
JournalJournal of Bacteriology
Issue number5
Publication statusPublished - 2007


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