Cognitive variability and the onset of Alzheimer's disease

Rachael Mumme

doi:10.26182/2718-rc88

Cognitive variability and the onset of Alzheimer's disease

Rachael Mumme

School of Psychological Science

Research output: Thesis › Doctoral Thesis

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Abstract

There is increasing interest in identifying markers of future Alzheimer's disease (AD) risk. One proposition is Intra-individual Variability (IIV) which measures individual cognitive variability at a single time point. This thesis explored IIV as a construct, particularly as it relates to AD. Various analyses including a meta-analysis, factor analysis, and latent growth modelling, found IIV was moderately associated with subsequent cognitive decline/dementia, however, IIV could not be conceptualised as a unitary construct. Instead, IIV calculated from complex tasks only showed sensitivity to pre-diagnosis AD. These findings offer guidance to the field around how to conceptualise and measure IIV in AD.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Weinborn, Michael, Supervisor Rainey-Smith, Stephanie, Supervisor Bucks, Romola, Supervisor Maruff, Paul, Supervisor, External person
Thesis sponsors	Australian Government Research Training Program
Award date	19 Dec 2021
DOIs	https://doi.org/10.26182/2718-rc88
Publication status	Unpublished - 2022

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10.26182/2718-rc88

THESIS - DOCTOR OF PHILOSOPHY - MUMME, Rachael Elizabeth - 2022
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Cite this

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AB - There is increasing interest in identifying markers of future Alzheimer's disease (AD) risk. One proposition is Intra-individual Variability (IIV) which measures individual cognitive variability at a single time point. This thesis explored IIV as a construct, particularly as it relates to AD. Various analyses including a meta-analysis, factor analysis, and latent growth modelling, found IIV was moderately associated with subsequent cognitive decline/dementia, however, IIV could not be conceptualised as a unitary construct. Instead, IIV calculated from complex tasks only showed sensitivity to pre-diagnosis AD. These findings offer guidance to the field around how to conceptualise and measure IIV in AD.

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Cognitive variability and the onset of Alzheimer's disease

Abstract

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