Cognitive variability and the onset of Alzheimer's disease

Rachael Mumme

Research output: ThesisDoctoral Thesis

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Abstract

There is increasing interest in identifying markers of future Alzheimer's disease (AD) risk. One proposition is Intra-individual Variability (IIV) which measures individual cognitive variability at a single time point. This thesis explored IIV as a construct, particularly as it relates to AD. Various analyses including a meta-analysis, factor analysis, and latent growth modelling, found IIV was moderately associated with subsequent cognitive decline/dementia, however, IIV could not be conceptualised as a unitary construct. Instead, IIV calculated from complex tasks only showed sensitivity to pre-diagnosis AD. These findings offer guidance to the field around how to conceptualise and measure IIV in AD.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Weinborn, Michael, Supervisor
  • Rainey-Smith, Stephanie, Supervisor
  • Bucks, Romola, Supervisor
  • Maruff, Paul, Supervisor, External person
Thesis sponsors
Award date19 Dec 2021
DOIs
Publication statusUnpublished - 2022

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