Cognitive impairment in people with diabetes-related foot ulceration

Ranita Siru, Melanie S. Burkhardt, Wendy A. Davis, Jonathan Hiew, Laurens Manning, Jens Carsten Ritter, Paul E. Norman, Ashley Makepeace, Peter Gerry Fegan, David G. Bruce, Timothy M.E. Davis, Emma J. Hamilton

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Aims: To determine whether there is an excess of cognitive impairment in patients with type 2 diabetes and foot ulceration. Methods: 55 patients with type 2 diabetes and foot ulcers attending Multidisciplinary Diabetes Foot Ulcer clinics (MDFU cohort) were compared with 56 patients with type 2 diabetes attending Complex Diabetes clinics (CDC cohort) using commonly used screening tests for cognitive impairment (Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MOCA)), as well as foot self-care, mood and health literacy. MMSE was also compared between the MDFU cohort and a historical community-based cohort of patients with type 2 diabetes (FDS2 cohort). Results: Median MMSE scores were the same in all three groups (28/30). Median MOCA scores did not differ between the MDFU and CDC cohorts (25/30). There were no significant differences in the percentages of patients with MMSE ≤ 24 or MOCA ≤ 25 between MDFU and CDC cohorts (3.6% versus 10.7%, p = 0.27 and 56.4% versus 51.8%, p = 0.71, respectively), find-ings that did not change after adjustment for age, sex, education, diabetes duration, and random blood glucose. Conclusions: Using conventionally applied instruments, patients with type 2 diabetes and foot ulceration have similar cognition compared with patients without, from either hospital-based clinic or community settings.

Original languageEnglish
Article number2808
JournalJournal of Clinical Medicine
Issue number13
Publication statusPublished - 1 Jul 2021


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