Cognitive impairment in heart failure patients: association with abnormal circadian blood pressure rhythm: a review from the HOPE Asia Network

Takahiro Komori, Satoshi Hoshide, Yuda Turana, Guru Prasad Sogunuru, Kazuomi Kario, Ji Guang Wang, Yook Chin Chia, Peera Buranakitjaroen, Chen Huan Chen, Hao Min Cheng, Takeshi Fujiwara, Yan Li, Minh Van Huynh, Michiaki Nagai, Jennifer Nailes, Sungha Park, Markus Schlaich, Jinho Shin, Saulat Siddique, Jorge SisonArieska Ann Soenarta, Apichard Sukonthasarn, Jam Chin Tay, Boon Wee Teo, Kelvin Tsoi, Yuda Turana, Narsingh Verma, Tzung Dau Wang, Yuqing Zhang

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Cognitive impairment (CI) is frequently a comorbid condition in heart failure (HF) patients, and is associated with increased cardiovascular events and death. Numerous factors contribute to CI in HF patients. Decreased cerebral blood flow, inflammation, and activation of neurohumoral factors are all thought to be factors that exacerbate CI. Hypoperfusion of the brain due to decreased systemic blood flow, cerebral venous congestion, and atherosclerosis are the main mechanism of CI in HF patients. Abnormal circadian BP rhythm is one of the other conditions associated with CI. The conditions in which BP does not decrease sufficiently or increases during the night are called non-dipper or riser BP patterns. Abnormal circadian BP rhythm worsens CI in HF patients through cerebral congestion during sleep and atherosclerosis due to pressure overload. Interventions for CI in HF patients include treatment for HF itself using cardiovascular drugs, and treatment for fluid retention, one of the causes of abnormal circadian rhythms. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)261-270
Number of pages10
JournalHypertension Research
Volume47
Issue number2
Early online date26 Sept 2023
DOIs
Publication statusPublished - Feb 2024

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