Cognitive functioning and the hippocampus in older adults with Type 2 diabetes

Nicole Terese Milne

doi:10.4225/23/5a94ae83771df

Cognitive functioning and the hippocampus in older adults with Type 2 diabetes

Nicole Terese Milne

School of Psychological Science

Research output: Thesis › Doctoral Thesis

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Abstract

Cognitive functioning and hippocampal volumes in older adults with Type 2 diabetes mellitus (T2DM) were examined, revealing that T2DM patients are not a cognitively homogeneous group, with -50% exhibiting impaired functioning. Hippocampal asymmetry and reduced right hippocampal volume were associated with poorer cognition cross-sectionally, with reduced right hippocampal volume predicting cognitive decline. These findings are in the opposite direction to those in normal ageing and Alzheimer's disease, where the reductions are greater in the left than right hippocampus. A sizeable proportion of older adults with T2DM have cognitive dysfunction, which is related to selective atrophy in the right hippocampus.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Bucks, Romola, Supervisor Bruce, David, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	30 Dec 2017
DOIs	https://doi.org/10.4225/23/5a94ae83771df
Publication status	Unpublished - 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.4225/23/5a94ae83771df

THESIS - DOCTOR OF PHILOSOPHY - MILNE Nicole Terese - 2017
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Cite this

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abstract = "Cognitive functioning and hippocampal volumes in older adults with Type 2 diabetes mellitus (T2DM) were examined, revealing that T2DM patients are not a cognitively homogeneous group, with -50\% exhibiting impaired functioning. Hippocampal asymmetry and reduced right hippocampal volume were associated with poorer cognition cross-sectionally, with reduced right hippocampal volume predicting cognitive decline. These findings are in the opposite direction to those in normal ageing and Alzheimer's disease, where the reductions are greater in the left than right hippocampus. A sizeable proportion of older adults with T2DM have cognitive dysfunction, which is related to selective atrophy in the right hippocampus.",

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AB - Cognitive functioning and hippocampal volumes in older adults with Type 2 diabetes mellitus (T2DM) were examined, revealing that T2DM patients are not a cognitively homogeneous group, with -50% exhibiting impaired functioning. Hippocampal asymmetry and reduced right hippocampal volume were associated with poorer cognition cross-sectionally, with reduced right hippocampal volume predicting cognitive decline. These findings are in the opposite direction to those in normal ageing and Alzheimer's disease, where the reductions are greater in the left than right hippocampus. A sizeable proportion of older adults with T2DM have cognitive dysfunction, which is related to selective atrophy in the right hippocampus.

KW - Diabetes

KW - Hippocampus

KW - MRI

KW - Neuroimaging

KW - Neuropsychology

KW - Cognition

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Cognitive functioning and the hippocampus in older adults with Type 2 diabetes

Abstract

UN SDGs

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