Cognitive functioning and the hippocampus in older adults with Type 2 diabetes

Nicole Terese Milne

Research output: ThesisDoctoral Thesis

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Abstract

Cognitive functioning and hippocampal volumes in older adults with Type 2 diabetes mellitus (T2DM) were examined, revealing that T2DM patients are not a cognitively homogeneous group, with -50% exhibiting impaired functioning. Hippocampal asymmetry and reduced right hippocampal volume were associated with poorer cognition cross-sectionally, with reduced right hippocampal volume predicting cognitive decline. These findings are in the opposite direction to those in normal ageing and Alzheimer's disease, where the reductions are greater in the left than right hippocampus. A sizeable proportion of older adults with T2DM have cognitive dysfunction, which is related to selective atrophy in the right hippocampus.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Bucks, Romola, Supervisor
  • Bruce, David, Supervisor
Thesis sponsors
Award date30 Dec 2017
DOIs
Publication statusUnpublished - 2017

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Type 2 Diabetes Mellitus
Hippocampus
Cognition
Atrophy
Alzheimer Disease
Cognitive Dysfunction
Direction compound

Cite this

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title = "Cognitive functioning and the hippocampus in older adults with Type 2 diabetes",
abstract = "Cognitive functioning and hippocampal volumes in older adults with Type 2 diabetes mellitus (T2DM) were examined, revealing that T2DM patients are not a cognitively homogeneous group, with -50{\%} exhibiting impaired functioning. Hippocampal asymmetry and reduced right hippocampal volume were associated with poorer cognition cross-sectionally, with reduced right hippocampal volume predicting cognitive decline. These findings are in the opposite direction to those in normal ageing and Alzheimer's disease, where the reductions are greater in the left than right hippocampus. A sizeable proportion of older adults with T2DM have cognitive dysfunction, which is related to selective atrophy in the right hippocampus.",
keywords = "Diabetes, Hippocampus, MRI, Neuroimaging, Neuropsychology, Cognition",
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Milne, NT 2017, 'Cognitive functioning and the hippocampus in older adults with Type 2 diabetes', Doctor of Philosophy, The University of Western Australia. https://doi.org/10.4225/23/5a94ae83771df

Cognitive functioning and the hippocampus in older adults with Type 2 diabetes. / Milne, Nicole Terese.

2017.

Research output: ThesisDoctoral Thesis

TY - THES

T1 - Cognitive functioning and the hippocampus in older adults with Type 2 diabetes

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PY - 2017

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N2 - Cognitive functioning and hippocampal volumes in older adults with Type 2 diabetes mellitus (T2DM) were examined, revealing that T2DM patients are not a cognitively homogeneous group, with -50% exhibiting impaired functioning. Hippocampal asymmetry and reduced right hippocampal volume were associated with poorer cognition cross-sectionally, with reduced right hippocampal volume predicting cognitive decline. These findings are in the opposite direction to those in normal ageing and Alzheimer's disease, where the reductions are greater in the left than right hippocampus. A sizeable proportion of older adults with T2DM have cognitive dysfunction, which is related to selective atrophy in the right hippocampus.

AB - Cognitive functioning and hippocampal volumes in older adults with Type 2 diabetes mellitus (T2DM) were examined, revealing that T2DM patients are not a cognitively homogeneous group, with -50% exhibiting impaired functioning. Hippocampal asymmetry and reduced right hippocampal volume were associated with poorer cognition cross-sectionally, with reduced right hippocampal volume predicting cognitive decline. These findings are in the opposite direction to those in normal ageing and Alzheimer's disease, where the reductions are greater in the left than right hippocampus. A sizeable proportion of older adults with T2DM have cognitive dysfunction, which is related to selective atrophy in the right hippocampus.

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KW - Hippocampus

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KW - Neuropsychology

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DO - 10.4225/23/5a94ae83771df

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