[Truncated] The existing literature on symptoms of thought disorder in schizophrenia does not present a clear picture of the underlying mechanisms involved in these symptoms. This thesis focused on a specific subset of theoretically defined symptoms, namely, discourse coherence disturbance which include symptoms which reflect an inability to maintain a discourse plan. This thesis comprises three studies employing cognitive or physiological measures in the attempt to discover the physiological and cognitive mechanisms underlying symptoms of discourse coherence disturbance in schizophrenia. The first study was a series of case studies investigating cognitive performance in patients with schizophrenia exhibiting symptoms of discourse coherence disturbance. Eight patients with a DSM-IV and ICD-10 diagnosis of schizophrenia exhibiting varying degrees of discourse coherence disturbance were compared to a group of nineteen comparison volunteers. Based on four current theories of discourse coherence disturbance, a range of cognitive areas, including short and long-term memory, semantic priming, contextual naming, working memory, verbal fluency, error-monitoring, and inhibition were explored.
|Qualification||Doctor of Philosophy|
|Publication status||Unpublished - 2002|